CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033894
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 MKL/myocardin-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 Mkl1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
57AEPSLQAKQLKLKRAacetylation[1]
546LTRMLQQKQQLVELLubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 705 AA 
Protein Sequence
MPPLKSPAAF HEQRRSLERA RTEDYLKRKI RSRPERAELV RMHILEETSA EPSLQAKQLK 60
LKRARLADDL NEKIAQRPGP MELVEKNILP VESSLKEAII VGQVNYPKVA DSSSFDEDSS 120
DALSPEQPAS HESQGSVPSP LESRVSDPLP SATSISPTQV LSQLPMAPDP GETLFLAEQP 180
PLPPAPLLPP SLANGSIVPT AKPAPTLIKQ SQPKSASEKS QRSKKAKELK PKVKKLKYHQ 240
YIPPDQKQDK GAPAMDSSYA KILQQQQLFL QLQILNQQQQ QQQQQHYNYQ AILPAPPKPS 300
AETPGSSAPT PSRSLSTSSS PSSGTPGPSG LARQSSTALA AKPGALPANL DDMKVAELKQ 360
ELKLRSLPVS GTKTELIERL RAYQDQVSPA PGAPKAPATT SVLSKAGEVV VAFPAALLST 420
GSALVTAGLA PAEMVVATVT SNGMVKFGST GSTPPVSPTP SERSLLSTGD ENSTPGDAFG 480
EMVTSPLTQL TLQASPLQIV KEEGARAASC CLSPGARAEL EGLDKDQMLQ EKDKQIEELT 540
RMLQQKQQLV ELLRLQLEQQ KRAQQPAPAS SPVKRESGFS SCQLSCQPQG SAHAFGSGLV 600
VPTTNHGDTQ APAPESPPVV VKQEAGPPEP DLAPSSQLLL GSQGTSFLKR VSPPTLVTDS 660
TGTHLILTVT NKSADGPGLP AGSPQQPLSQ PGSPAPGPPA QMDLE 705 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0051145; P:smooth muscle cell differentiation; IEA:Compara. 
Interpro
 IPR004018; RPEL_repeat.
 IPR003034; SAP_dom. 
Pfam
 PF02755; RPEL
 PF02037; SAP 
SMART
 SM00707; RPEL
 SM00513; SAP 
PROSITE
 PS51073; RPEL
 PS50800; SAP 
PRINTS