UniProt Accession

 SNP25_HUMAN; P60880; B2RAU4; D3DW16; D3DW17; P13795; P36974; P70557; P70558; Q53EM2; Q5U0B5; Q8IXK3; Q96FM2; Q9BR45 

Genbank Protein ID

 L19760; L19761; D21267; BT019684; AK223617; AK289647; AK314359; AL023913; AL023913; AL023913; CH471133; CH471133; CH471133; CH471133; BC010647 

Genbank Nucleotide ID

 AAC37545.1; AAC37546.1; BAA22370.1; AAV38490.1; BAD97337.1; BAF82336.1; BAG36991.1; CAB42860.1; CAC34534.1; CAD56158.1; EAX10346.1; EAX10349.1; EAX10350.1; EAX10352.1; AAH10647.1 

Protein Name

 Synaptosomal-associated protein 25 

Protein Synonyms/Alias

 SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein 

Gene Name

 SNAP25 

Gene Synonyms/Alias

 SNAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	LQLVEESKDAGIRTL	ubiquitination	[1]
201	EANQRATKMLGSG**	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. 

Sequence Annotation

 DOMAIN 19 81 t-SNARE coiled-coil homology 1.
 DOMAIN 140 202 t-SNARE coiled-coil homology 2.
 REGION 1 75 Interaction with CENPF (By similarity).
 MOD_RES 138 138 Phosphothreonine (By similarity).
 MOD_RES 187 187 Phosphoserine (By similarity).
 LIPID 85 85 S-palmitoyl cysteine (By similarity).
 LIPID 88 88 S-palmitoyl cysteine (By similarity).
 LIPID 90 90 S-palmitoyl cysteine (By similarity).
 LIPID 92 92 S-palmitoyl cysteine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Repeat; Synapse; Synaptosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030426; C:growth cone; ISS:HGNC.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0031201; C:SNARE complex; IDA:UniProtKB.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0014047; P:glutamate secretion; TAS:Reactome.
 GO:0001504; P:neurotransmitter uptake; NAS:UniProtKB.
 GO:0050796; P:regulation of insulin secretion; TAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0016081; P:synaptic vesicle docking involved in exocytosis; NAS:UniProtKB. 

Interpro

 IPR000928; SNAP-25.
 IPR000727; T_SNARE_dom. 

Pfam

 PF00835; SNAP-25
 PF05739; SNARE 

SMART

 SM00397; t_SNARE 

PROSITE

 PS50192; T_SNARE 

PRINTS