| Tag | Content |
|---|
| CPLM ID | CPLM-017817 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-like-conjugating enzyme ATG10 |
Protein Synonyms/Alias | Autophagy-related protein 10; APG10-like; mAPG10 |
Gene Name | Atg10 |
Gene Synonyms/Alias | Apg10l |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 44 | CSDGYMCKTQFRIKN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis. |
Sequence Annotation | ACT_SITE 165 165 Glycyl thioester intermediate (Probable). |
Keyword | Autophagy; Complete proteome; Cytoplasm; Ligase; Protein transport; Reference proteome; Transport; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 215 AA |
Protein Sequence | MEDEFFGEKS FQHYCAEFIR HSQQIGDGWE WRTAKECSDG YMCKTQFRIK NEASTPHVGT 60
PASVLTCLPT EENLELPMDD SEVTRPAAVA EVIKHEYHVL YSCSYQVPVL YFRASFLDGR 120
PLALEDIWEG VHECYKPRLL QGPWDTITQQ EHPILGQPFF VLHPCKTNEF MTAVLKNSQK 180
INRNVNYITS WLSLVGPVVG LNLPLSYAKA TSQSE 215 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0019777; F:Atg12 ligase activity; IMP:UniProtKB. GO:0034263; P:autophagy in response to ER overload; IEA:Compara. GO:0031401; P:positive regulation of protein modification process; IDA:MGI. GO:0006497; P:protein lipidation; IDA:MGI. GO:0032446; P:protein modification by small protein conjugation; IEA:Compara. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
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PRINTS | |