CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011705
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynein heavy chain 14, axonemal 
Protein Synonyms/Alias
 Axonemal beta dynein heavy chain 14; Ciliary dynein heavy chain 14 
Gene Name
 DNAH14 
Gene Synonyms/Alias
 C1orf67 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
185CLPRKSPKSLYNPYDubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). 
Sequence Annotation
 NP_BIND 1164 1171 ATP (Potential).
 NP_BIND 1427 1434 ATP (Potential).
 MOTIF 1164 1171 GPAGTGKT motif (By similarity).
 CARBOHYD 1818 1818 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Glycoprotein; Microtubule; Motor protein; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3507 AA 
Protein Sequence
METFIPIDLT TENQEMDKEE TKTKPRLLRY EEKKYEDVKP LETQPAEIAE KETLEYKTVR 60
TFSESLKSEK TEDYLRESII QQHMVSPEPA SLKEKGKSRR KKDQTHACPN VRKARPVSYD 120
RTEPKDDDVI RNIIRLREKL GWQTILPQHS LKYGSSKIAI QKITLKKPLE DDGEFVYCLP 180
RKSPKSLYNP YDLQVVSAHT AKHCKEFWVI TASFISKVIN IVGSVKEVEL IPTLEWLSER 240
RHYYLLRQFK IFSDFRMNKA FVTWKLNVKR IKTEKSRSFL YHHLFLADDL FQTCLVYIRG 300
LCEDAINLKN YNDHENNLSA ICLVKLDSSR TYSLDEFCEE QLQQATQALK QLEDIRNKAI 360
SEMKSTFLKV AEKNEIKEYF ESKLSEDDTT HFKLPKYRRL LETFFKFVML VDYIFQELIR 420
QLMNTAVTLL LELFNGSAGM PFSVEKKNEN LIRTFKDNSF PTGKTTNDCE ELVDNSKLHA 480
ISVQKSEVKT DTDINEILNS VEVGKDLRKT YAPIFEVNLC LRIPAESDSS ENSKENFHES 540
DQCPEECVMF EDEMSENKDN CVKKHSSEEL LPKAKKSKEI SYNLEDIISD TEIETEFENK 600
YMYYEFPEFP TNLFIDPNRL EFSVKIQNML TNMEKCITTI TPLCQDPQLS IFIDLVSIMD 660
LPNKTGSIIH YKEQTRWPDC HILFETDPAY QNIIVNLLTI IGNSMGLVNA YSHKFIKYCT 720
MTEKAKIMSM KISSMGELTS KEFEAILNRF RNYFRHIVNM AIEKRIGIFN VVSLDYQSEC 780
LLYIDNVIHM SHTLIQSVIE KKNKNLLEVV ESSLQQLECD PTEIEEFLEH FIFLNAISSK 840
ISKLEKEFLT MSQLYSVAKH HQIHISEEQI AIFQVLLLKF SQLKSSMKLS KINKDTAITK 900
FRDNLEACIS GLHVDVGNLK AKIRTPLLLC AGTQVSTAME MIQTLSGEAA SLTNKAKAYS 960
HYQDCFSDSQ SHMHSVNVEE ITQIVLSEIS DIEGDLTLRK KLWEAQEEWK RASWEWRNSS 1020
LQSIDVESVQ RNVSKLMHII SVLEKGLPKS DMVTHLKQVV TEFKQELPII IALGNPCLKP 1080
RHWEALQEII GKSVPLDKNC KVENLLALKM FQYENEINDM STSATNEAAL EKMLFKIIDF 1140
WNTTPLPLIL HHTEIYSIFI IPSIDDISAQ LEESQVILAT IKGSPHIGPI KDLVNEWDQN 1200
LTLFSYTLEE WMNCQRNWLY LEPVFHSSEI RRQLPAETEL FSQVISMWKK IMSKIQNKQN 1260
ALQITTSAGV LEILQNCNIH LEHIKKSLED YLEVKRLIFP RFYFLSNAEL LDILADSRNP 1320
ESVQPHLVKC FENIKQLLIW KQDIGPPAVK MLISAEGEGL VLPKKIRVRS AVEQWLVNVE 1380
KSMFDVLKKE RYIYNIILLF QSQIMFYNDC VKSFVSSYSR EKLEKVHAGL MCHLEEVADL 1440
VVLDTSNSRT KAILGALLIL YVHCRDIVIN LLLKNIFNAE DFEWTRHLQY KWNEKQKLCY 1500
VSQGNASFTY GYEYLGCTSR LVITPLTDRC WLTLMEALHL NLGGCPAGPA GTGKTETVKD 1560
LAKSLGKHCV VFNCFEDLDY KIVRKFFFGL VQSGAWSCFD EFNLIDLEVL SVIASQILTI 1620
KAAKDNYSAR FVLEGKEIRI NMSCAVFITM NPRYGGGVEL PDNLKSLFRP VAMMVPHYQM 1680
IAEIILFSFG FKSANSLSGK LTNLYELARK QLSQQDHYNF GLRSLKIVLI MAGTKKREFK 1740
CLSEADETLI VIEAIREASL PKCPPEDVPL FENIIGDIFP EVTVLKVNQL ALEKVIYTAT 1800
QQLGLQNWSS QKEKIIQFYN QLQVCVGVML VGPTGGGKTT VRRILEKALT LLPIADFLSV 1860
AERKSASKIS ERKGKVDICV LNPKCVTLSE LYGQLDPNTM EWTDGLLSAT IRSYVYFNTP 1920
KNTKKDIDLR LKSRISDLSN VFKLDSSDTT ETDDNIFEEI EKVVKIPENH NFDWQWIILD 1980
GPVDTFWVEN LNSVLDDTRT LCLANSERIA LTNKIRVIFE VDNLSQASPA TVSRCAMVYM 2040
DPVDLGWEPY VKSWLLKTSK IISQSGVDCL EFMIKNSVTD GLQFIRNRQK FQPYPMEDIT 2100
VVITLCRILD AFFDFMGKNG GFEQSDDLND TSSKEANSQR ESVTFKDIEK RDENTWYPEK 2160
NPDKLTKIIQ KLFVFAFTWA FGGALNREDE HRENIPFCPS LEPDSLAKVT YDFDKLVHEL 2220
FGNSSQVGWK HWGQSQGRRR KGNCINLPTG ECSIFGYFVD IEQCEFIPWS DLVPNDQTLI 2280
QRGTSLLTNL QRSGGNFLKI TECGECINYT ATRDTTCLSF LMSLLLKNSC PVLLTGESGV 2340
GKTAAINQML EKLEGPGAFD IKHGSILGDT LLYSEIKKSS SLKQNITILI PETHKTATGS 2400
SDNPTKKPEV RTNKKLLKNN DHKGVVVSTI NFSTNVTAAK TKEMILKKLI RRTKDTLGAP 2460
KNNRILIFID DMNMPVSDMY GAQPPLELIR QLLDLGGVYD TEKNTWKNIQ DLSIVAACVP 2520
VVNDISPRLL KHFSMLVLPH PSQDILCTIF QAHLGIYFSI NNFTPEVQKS KDQIISCSLA 2580
IYHQVRQNML PTPTKCHYMF NLRDMFKLLL GLLQADRTVV NSKEMAALLF VHEATRVFHD 2640
RLIDFTDKSL FYRLLSRELE NCFQIGIDGC GKKTCATLAC YLTDNKLYRV PISHKCAYIE 2700
FKEVFKKVFI HAGLKGKPTV LMVPNLNIEQ DSFLEDLNYI ISSGRIPDLF ENVELDSIAM 2760
KIRYLTEQSG HMDNRQSLLS FFQKRIYKNL HIFVIMSPEG PSFRQNCRVY PSMISSCTID 2820
WYERWPEEAL LIVANSFLKE KVNFENRENL KEKLAPTCVQ IHKSMKDLNR KYFEETGRFY 2880
YTTPNSYLQF METFAHILRA REEEMQTKRD RFHMGLSTIL EATTLVTEMQ EELLILGPQV 2940
EQKTKETETL MEKLRKDSQV VEKVQMLVKQ DEEIVAEEVR IVEDYAQKTA NELKSVLPAF 3000
DKAIVALNAL DKADVAELRV YTRPPFLVLT VMNAVCILLQ KKPNWATAKL LLSETGFLKK 3060
LINLDKDSIP DKVFVKLKKI VTLPDFNPHK ISLVSVACCS LCQWVIALNN YHEVQKVVGP 3120
KQIQVAEAQN VLKIARQRLA EKQRGLQLVE EHLLFLQAAY KDTVAEKQLL ANRKTMASRR 3180
FQCASVLLTV LEDEKTRWQE TINQIDNKLE GILGDILLSA ACIVYSGILT PEFRQLIVNK 3240
WETFCIENGI SLSSKFSLIK VMAQKYEISR WHNQGLPHGQ YSVENAILIK NGQQWPLLID 3300
PHRQAHKWIR QMEGSRLQKL SIEDSNYTKK IENAMKTGGS VLLQNLLETL APGLKAILKK 3360
DIYQKKGHYF IRVGDAEFEY NSNFRLYLST EIDNPHFLPS VYNFVTMINF TVTFQGLQDQ 3420
LLSTVVTHEV PHLEDQRSKL LESISLDAIT LEELEEKTLN LLQKALGSIL DDDKIVDTLR 3480
KSKMTSNEIS KRIEATKKAE SEIQAIRKNY LPIATRGALL YFLVADLTQI NYMYQFSLDW 3540
FHQVFVSSVV SKSKEQEHSF KREKVSPKEV HEFISISKEP NLENEKNLLD KHIKSAIDML 3600
TKSIFKVVSS ALFNEDKLCF SFRLCTVIMQ NNANGNLIQD DIGFLPEEEW NIFLYSGILI 3660
NIKSALSQSR LTSTFEIGES QHLQWLSDSR WRQCQYVSTH LEPFSLLCKS LLSNVSQWDT 3720
FKNSKAVYSL ISTPFSSENA SLEENTKPPE ETELLNENKE TCNPINFPWE KLTSFQRLIL 3780
VKVLRPESLN NSVRKFITEK MGNKYLQRTG VNLKDAYKGS NARTPLILIQ THGIDLTNIL 3840
LRFAQELKGT THHVTIISLG RDQAAKAEDL ILKALTKTQQ WVFLQNCHLA TSFMPRLCTI 3900
VESFNSPNVT IDPEFRLWLS SKSYSSFPIP VLKKGLKIAV ESPQGLKSNL LQTFGCTGSG 3960
EVTEEIFENP DCGQWWKKLL FSLCFFNAVI NERKNYGILG WNIAYKFNSS DLGVAIKVLE 4020
NSLRGQPSIS WQALRYLIGE VIYGGRVIDN WDKRCLKTLL YKFCNPEVLK DDFSFSRSAS 4080
IKDYIHIIQS LPDDDLPEVL GIHPEAIRSC WETQGEKFIE NLIAMQPKTT TANLMIRPEQ 4140
SKDELVMEIL SDLLKRLPLT VEKEEIAVGT PSTLKSMMSS SIWESLSKNL KDHDPLIHCV 4200
LLTFLKQEIK RFDKLLFVIH KSLKDLQLAI KGEIILTQEL EEIFNSFLNM RVPTLWQKHA 4260
YRSCKPLSSW IDDLIQRLNF FNTWAKVAYT AIQRRYMRFV TVWKQSIPST SQKCKHPEDS 4320
ENNFFEGFPS RYWLPAFFFP QAFLAAVLQD YGRSRGIAVD ALTFTHHVIS NTTDKDEKFS 4380
VFMPKKLNIV RRAFKGSASS HTGVYIFGLF IEGARWNREQ KILEDSLPLE MCCDFPDIYF 4440
LPTKISTKTP NASNQTDSEL YAFECPVYQT PERSRILATT GLPTNFLTSV YLSTKKPPSH 4500
WITMRVALLC EKNEK 4515 
Gene Ontology
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR026983; DHC_fam.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF12780; AAA_8
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
  
PROSITE
  
PRINTS