CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020577
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat domain-containing protein 1 
Protein Synonyms/Alias
 Cardiac ankyrin repeat protein 
Gene Name
 Ankrd1 
Gene Synonyms/Alias
 Carp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
13VEELVTGKKNSNGAAubiquitination[1]
14EELVTGKKNSNGAAGubiquitination[1]
41EAAVALEKQEDLKTLubiquitination[1]
46LEKQEDLKTLPANSVubiquitination[1]
54TLPANSVKQGEEQRKubiquitination[1]
103RKKYKKTKVPVVKEPubiquitination[1]
203GGNADVLKLLLNKGAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. 
Sequence Annotation
 REPEAT 152 181 ANK 1.
 REPEAT 185 214 ANK 2.
 REPEAT 218 247 ANK 3.
 REPEAT 251 280 ANK 4.
 REPEAT 284 315 ANK 5.  
Keyword
 ANK repeat; Coiled coil; Complete proteome; Nucleus; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MMVLRVEELV TGKKNSNGAA GEFLPGEFRN GEYEAAVALE KQEDLKTLPA NSVKQGEEQR 60
KSEKLREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK KTKVPVVKEP EPEIMTEPVD 120
VPRFLKAALE NKLPVVEKFL SDKNSPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE 180
FRDMLESTAI HWACRGGNAD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA 240
CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LMTFGADLKV KNCAGKTPMD LVLHWQSGTK 300
AIFDSLKENA YKNSRIATF 319 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031674; C:I band; IDA:BHF-UCL.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0001105; F:RNA polymerase II transcription coactivator activity; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IDA:MGI.
 GO:0055008; P:cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0035690; P:cellular response to drug; IDA:UniProtKB.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0071347; P:cellular response to interleukin-1; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0071407; P:cellular response to organic cyclic compound; IEA:Compara.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0071356; P:cellular response to tumor necrosis factor; IEA:Compara.
 GO:2000279; P:negative regulation of DNA biosynthetic process; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0050714; P:positive regulation of protein secretion; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0035994; P:response to muscle stretch; IEA:Compara.
 GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS