Tag | Content |
---|
CPLM ID | CPLM-016842 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tensin-like C1 domain-containing phosphatase |
Protein Synonyms/Alias | C1 domain-containing phosphatase and tensin homolog; C1-TEN; Tensin-2 |
Gene Name | Tenc1 |
Gene Synonyms/Alias | Tns2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
---|
640 | YAEASVEKRRLCRSL | ubiquitination | [1] | 660 | PYAPELGKPANGDFG | ubiquitination | [1] | 1355 | NPDGATSKIFGFVAK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling (By similarity). |
Sequence Annotation | DOMAIN 122 294 Phosphatase tensin-type. DOMAIN 299 425 C2 tensin-type. DOMAIN 1131 1238 SH2. ZN_FING 31 79 Phorbol-ester/DAG-type. ACT_SITE 231 231 Phosphocysteine intermediate (By MOD_RES 455 455 Phosphoserine. MOD_RES 466 466 Phosphoserine. MOD_RES 481 481 Phosphoserine. MOD_RES 483 483 Phosphotyrosine. MOD_RES 832 832 Phosphoserine. MOD_RES 835 835 Phosphoserine. MOD_RES 913 913 Phosphothreonine. MOD_RES 1087 1087 Phosphoserine. |
Keyword | Alternative splicing; Cell junction; Cell membrane; Complete proteome; Hydrolase; Membrane; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome; SH2 domain; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1400 AA |
Protein Sequence | MKSSGPVERL LRALGRRDSS RATSRPRKAE PHSFREKVFR KKTPVCAVCK VTIDGTGVSC 60 RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 120 LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 180 KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV 240 IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS 300 PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL CISLEPALLL 360 KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK DQLDEAWADE RFPFQASVEF 420 VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGA LAHTRGPLDG 480 SPYAQVQRVP RQTPPAPSPE LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE 540 LDRLLGGCGV ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE 600 PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG PYPYAPELGK 660 PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP TAALYGLRLE REAAEGWSSE 720 VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH 780 SGYPALVTYG YGGAVPSYCP AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ 840 PRKLGYEISA EDGRDKYPLS GHLASTGPLA STESPEPSWR DGSSGHSTLP RSPRDPQCSA 900 SSELSGPSTP LHTSSPVQGK ESNRRQDTTR SPSLAPTQRL SPGEALPSVV QGVAEKTPEL 960 LTSSRPEQLD PSPFSQTSAP GSPNGWPQER SPGGHTNSAS PRSPVPTTLP GLRHAPWQGP 1020 RGTSDSPDGS PLTPVPTQMP WLVGSPEPPQ SSPTPAFPLA TSYDANGPIQ PPLPEKRHLP 1080 GSGQQPSPPA RSTNQHVTFA SPLPDVTQPP EHPLQENQSN VKFVQDTSKF WYKPHLSRDQ 1140 AIALLKDKDP GAFLIRDSHS FQGAYGLALK VATPPPSAQP WKGDPSEQLV RHFLIETGPK 1200 GVKIKGCPTE PYFGSLSALV SQHSISPISL PCCLRIPSKD PLEETPEAPV PTNMSTAADL 1260 LRQGAACSVL YLTSVETESL TGPQAVAKAS SAALSCSPVP VPAIVHFKVS AQGITLTDNQ 1320 RKLFFRRHYP VNSITFSSTD PQDRRWTNPD GATSKIFGFV AKKPGSPWEN VCHLFAELDP 1380 DQPASAIVTF ITKVLLGQRK 1400 |
Gene Ontology | GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. GO:0019725; P:cellular homeostasis; IMP:MGI. GO:0032963; P:collagen metabolic process; IMP:MGI. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0001822; P:kidney development; IMP:MGI. GO:0035264; P:multicellular organism growth; IMP:MGI. GO:0048871; P:multicellular organismal homeostasis; IMP:MGI. GO:0008285; P:negative regulation of cell proliferation; IEA:Compara. GO:0014850; P:response to muscle activity; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |