CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038272
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nebulin-related-anchoring protein 
Protein Synonyms/Alias
  
Gene Name
 Nrap 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
77TPLNLTLKKSVAAMGubiquitination[1]
89AMGGIDGKEDGEPFKubiquitination[1]
165DREQQQGKGSFPAMIubiquitination[1]
180TPAYQRAKAANQLASubiquitination[1]
192LASQVQYKRGHDERVubiquitination[1]
215TPELLRAKAGGQLQNubiquitination[1]
1187TPNLLHAKYSNQITNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1692 AA 
Protein Sequence
MNVQACSRCG YGVYPAEKIS CIDQTWHKAC FHCEVCKMML SVNNFVSHQK KPYCHAHNPK 60
NNTFTSVYHT PLNLTLKKSV AAMGGIDGKE DGEPFKSVLH WDMKSKAGAG AASRLMNERD 120
YWPGYAEGNT WCPGALPDPE IVRMVEARQS LGEGYTEDRE QQQGKGSFPA MITPAYQRAK 180
AANQLASQVQ YKRGHDERVS TFTPVADTPE LLRAKAGGQL QNDVRYTEDG GQQRGKGSFP 240
AMITPAYQIA KRATELASDV RYHQQYHREM KGMASPVGAE GGMTKDSVDR CGQVYSEECD 300
EPRGKGSFPA MITPAYQNAK KANELVSDIK YRQDFHKMKG AAHFHSLAAQ DNLVLKRAQS 360
VSKLVSEVEY KKGLENSKGH SINYCETPQF RNVSKISKFT SDNKYKENYQ TQLRGHYDGV 420
GMDRRMLHAL KVGSLASNVA YKADYKHDVV DYNYLATATP FYQTTMRLVP LKDVNYRQNI 480
DRMKFSSVTN TPQIVQAKIN AQQLSHVNYR ADYERNKLNY TLPQDAPQLL KAKANAELFS 540
EVKYKEEYEK MKGRALGATD SKLLHSLQVA KMSSEVEYKK GFEESKTHFN LPMDMVNLRH 600
AKKAQALASD LDYRKKLHDY TVLPEDMKTQ WAKKAYGLQS ELQYKADLAW MRGVGWLTEG 660
SLNLEQAKKA GQLISEKNYR QRVDELKFTS VADSSQMEHA KKSQGLQNAV AYKAGNEQSV 720
HQYTISKDEP LFLRARANAA QLSETLYKSS WEKQKAKGFE LRLDSLAFLT AKAKRDLASE 780
VKYKEDYERS RGKLIGAKSA QGDSQMSHSL QMSKLQSDLE YKKGFEDTRS QCHISLDMVH 840
LVHARQAQHL ATDVGYRTAS HCFTALPTDM KVEWAKKAYG LQSDNQYRAD MKWMKGTGWV 900
ATGSLHVEQA KKAGELISEK KYRQHPDALK FTSIKDTPEM VQARISYTQA VDRLYREQGE 960
NVKHHYTQTA DLPEVLLAKL NAMNISETRY KESWSRLRDG GYKLRLDALP FQAAKASSEV 1020
ISDYKYKEAF ERMKGQMLGS RSLEDDLSLA HSVHATSLQS DVNYKKGFEH AKAHFHLPLD 1080
MVTLVHAKKA QTLASDQDYR HPLPQHTVLA EDLRLSCAKK AHKLQSENLY RSDLNFMRGV 1140
PCVVPGTLEI EGRKKASELI SESKYRQHPG SFKYTAVTDT PNLLHAKYSN QITNERLYKA 1200
AGEDARHQYT MTLGLPEFIR AKTNAANLSE AKYKEAWHNL RAQGYKLTID ALPFQAARAS 1260
GDIASDFLYR HEFVKERGQL IGVRNVSDDP RLLHCLRMGQ LQSENQYRKE AASSQAQCHL 1320
PMDMMYLVHA RKAQALASDH DYRTQCHEFT ALPEDLKMAW AKKAHALQSE FRYKADLMGM 1380
KGTGWLALQS PQIESAKKAG DLISETKYRK KPDSIKFTTV VDSPDLIHAK ESYMHCNERL 1440
YRLGDAASLH RYTPIPDHPD FTRARMNAMH LSDKVYRNAW EQSRAGGYDF RLDAIPFQTA 1500
RVSRDIASDF RYKEAFLRDR GLQIGYRSIS DDPRTTHFLR VGRLQSDNEY RKAFAKGRSQ 1560
FHSRADQPGF LQAKRSQQLA SDVLYRQPLP QHTSDPEQLG LKHARKAHQL QSDVKYKSDL 1620
NLTRGVGWTP PGSYKVEMAR RAAELANRRG PGIRGASVEP EAAAALGDHQ SRGVNPDASE 1680
ILHIHKKKTL LM 1692 
Gene Ontology
 GO:0030016; C:myofibril; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; TAS:MGI. 
Interpro
 IPR013998; Nebulin.
 IPR000900; Nebulin_35r-motif.
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM
 PF00880; Nebulin 
SMART
 SM00132; LIM
 SM00227; NEBU 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS51216; NEBULIN 
PRINTS
 PR00510; NEBULIN.