CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001509
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 47 
Protein Synonyms/Alias
 Neuronal enriched MAP interacting protein; Nemitin 
Gene Name
 WDR47 
Gene Synonyms/Alias
 KIAA0893 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25ILDFLNSKKLHISMLubiquitination[1, 2]
26LDFLNSKKLHISMLAubiquitination[2]
188KLSEAGFKASNNRLFubiquitination[1]
274IHVDKLLKPTKAAYAubiquitination[2]
277DKLLKPTKAAYADLLubiquitination[2]
290LLTPLISKLSPYPSSubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 10 42 LisH.
 DOMAIN 45 102 CTLH.
 REPEAT 604 643 WD 1.
 REPEAT 659 698 WD 2.
 REPEAT 706 748 WD 3.
 REPEAT 753 791 WD 4.
 REPEAT 798 837 WD 5.
 REPEAT 840 879 WD 6.
 REPEAT 886 918 WD 7.
 MOD_RES 285 285 Phosphothreonine.
 MOD_RES 292 292 Phosphoserine.
 MOD_RES 297 297 Phosphoserine.
 MOD_RES 312 312 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Microtubule; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 919 AA 
Protein Sequence
MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML FLRQLILDGQ 60
WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA MSAEDEPQHL EFTMQEAVQC 120
LHALEEYCPS KDDYSKLCLL LTLPRLTNHA EFKDWNPSTA RVHCFEEACV MVAEFIPADR 180
KLSEAGFKAS NNRLFQLVMK GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL 240
DLSLLSWLQN LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR 300
RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY PGVQNLSRSL 360
MLENTECHSI YEESPERDTP VDAQRPIGSE ILGQSSVSEK EPANGAQNPG PAKQEKNELR 420
DSTEQFQEYY RQRLRYQQHL EQKEQQRQIY QQMLLEGGVN QEDGPDQQQN LTEQFLNRSI 480
QKLGELNIGM DGLGNEVSAL NQQCNGSKGN GSNGSSVTSF TTPPQDSSQR LTHDASNIHT 540
STPRNPGSTN HIPFLEESPC GSQISSEHSV IKPPLGDSPG SLSRSKGEED DKSKKQFVCI 600
NILEDTQAVR AVAFHPAGGL YAVGSNSKTL RVCAYPDVID PSAHETPKQP VVRFKRNKHH 660
KGSIYCVAWS PCGQLLATGS NDKYVKVLPF NAETCNATGP DLEFSMHDGT IRDLAFMEGP 720
ESGGAILISA GAGDCNIYTT DCQRGQGLHA LSGHTGHILA LYTWSGWMIA SGSQDKTVRF 780
WDLRVPSCVR VVGTTFHGTG SAVASVAVDP SGRLLATGQE DSSCMLYDIR GGRMVQSYHP 840
HSSDVRSVRF SPGAHYLLTG SYDMKIKVTD LQGDLTKQLP IMVVGEHKDK VIQCRWHTQD 900
LSFLSSSADR TVTLWTYNG 919 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 
Interpro
 IPR006595; CTLH_C.
 IPR006594; LisH_dimerisation.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00668; CTLH
 SM00667; LisH
 SM00320; WD40 
PROSITE
 PS50897; CTLH
 PS50896; LISH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS