CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014154
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein disulfide-isomerase-like protein of the testis 
Protein Synonyms/Alias
  
Gene Name
 Pdilt 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
379KSSEEIPKYWDQEPVacetylation[1]
387YWDQEPVKKLVGKNFacetylation[1]
583EQPKPERKLDIKEELacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Probable redox-inactive chaperone involved in spermatogenesis (By similarity). 
Sequence Annotation
 DOMAIN 385 448 Thioredoxin.
 MOTIF 587 590 Prevents secretion from ER (Potential).
 CARBOHYD 55 55 N-linked (GlcNAc...) (Potential).
 CARBOHYD 337 337 N-linked (GlcNAc...) (Potential).  
Keyword
 Chaperone; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Isomerase; Reference proteome; Signal; Spermatogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 590 AA 
Protein Sequence
MELLWTPLLL LAACLSEVLG SPEMDTGINI SQPLHILEDH NLMVLTPAGL TQTLNETRFL 60
MVIFHNPTLK QSRKLAKELG KAAEIFGKGK NGLGFGKVDI TMETELKQEF DITHAPELKL 120
FYEGNRLEPI SCKDVVESTA LVVWLRRQIS KKALLFNNSN EVADFVKSRP LVIVGFFQDL 180
EEEVAELFYD TIKDFPELTF GAIQIKNSFG RFHVILDSVL VFKKGRVVKR QELINDSTNK 240
DYLNQVIKQQ LTGFVIEFNP ENKDLIYEMN ILNHMLLFIS KNSEPYSTII RHYRQISKEF 300
QNKILFVLVN SDEPKNKRIF EYFQISRVNV PSVQILNLSS DARYKMPTDN ITFESLKKFC 360
NSFLSRTAKK HKSSEEIPKY WDQEPVKKLV GKNFNVVVFD KEKDVFVMFY APWSEKCRVL 420
LPLLEELGIK YQNHSTVIIA KIDITANDIQ LANPEQYPFF RLFPTDSQEA VMYKGEHTMK 480
GFCDFLESHV KVRIEEDDEL LYIEQNEVAE EEVLAEPEMQ HIDKLPEKPP LKVEDTSKQD 540
RPAKESPALG SISQPEELER RKETAEKEKK VAQPKEQPKP ERKLDIKEEL 590 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR012336; Thioredoxin-like_fold.
 IPR013766; Thioredoxin_domain. 
Pfam
 PF00085; Thioredoxin 
SMART
  
PROSITE
 PS00014; ER_TARGET
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 
PRINTS