CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012777
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LON peptidase N-terminal domain and RING finger protein 2 
Protein Synonyms/Alias
 Neuroblastoma apoptosis-related protease; RING finger protein 192 
Gene Name
 LONRF2 
Gene Synonyms/Alias
 RNF192 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
489HCPLCKDKLSELLASubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
 REPEAT 23 58 TPR 1.
 REPEAT 59 91 TPR 2.
 REPEAT 197 230 TPR 3.
 REPEAT 231 264 TPR 4.
 REPEAT 266 298 TPR 5.
 REPEAT 447 483 TPR 6.
 DOMAIN 530 738 Lon.
 ZN_FING 449 487 RING-type.  
Keyword
 Alternative splicing; Complete proteome; Metal-binding; Polymorphism; Reference proteome; Repeat; TPR repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 754 AA 
Protein Sequence
MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML AGLAQPDRGL 60
CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG GLVRAVGLRD RPLSAENPGG 120
EPEAPGEGGP APEPRAPRDL LGCPRCRRLL HKPVTLPCGL TVCKRCVEPG PARPQVRRVN 180
VVLSGLLEKC FPAECRLRRL AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL 240
YLTMKNYEQA LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS 300
VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD AGSSENSSEK 360
SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK RQFPDDVEDA PDLNAPGKIP 420
KKDLSLQRSP NSETEESQGL SLDVTDFECA LCMRLLFEPV TTPCGHTFCL KCLERCLDHA 480
PHCPLCKDKL SELLASRNFN ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI 540
FVCAMAFPTV PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR 600
TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA ALHDSVHQQS 660
VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW WILAVLPLER KAQLAILGMT 720
SLKERLLAIR RILVIITRKM NSRQELANAR ERNN 754 
Gene Ontology
 GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR003111; Pept_S16_N.
 IPR015947; PUA-like_domain.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF02190; LON 
SMART
 SM00184; RING
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS