CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011936
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hyaluronidase-2 
Protein Synonyms/Alias
 Hyal-2; Hyaluronoglucosaminidase-2; Lung carcinoma protein 2; LuCa-2 
Gene Name
 HYAL2 
Gene Synonyms/Alias
 LUCA2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
148WVRNWQDKDVYRRLSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. 
Sequence Annotation
 DOMAIN 361 439 EGF-like.
 ACT_SITE 135 135 Proton donor (By similarity).
 LIPID 448 448 GPI-anchor amidated glycine (Potential).
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 CARBOHYD 103 103 N-linked (GlcNAc...) (Potential).
 CARBOHYD 357 357 N-linked (GlcNAc...) (Potential).
 DISULFID 47 340 By similarity.
 DISULFID 211 227 By similarity.
 DISULFID 365 376 By similarity.
 DISULFID 370 427 By similarity.
 DISULFID 429 438 By similarity.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Glycosidase; GPI-anchor; Hydrolase; Lipoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 473 AA 
Protein Sequence
MRAGPGPTVT LALVLAVSWA MELKPTAPPI FTGRPFVVAW DVPTQDCGPR LKVPLDLNAF 60
DVQASPNEGF VNQNITIFYR DRLGLYPRFD SAGRSVHGGV PQNVSLWAHR KMLQKRVEHY 120
IRTQESAGLA VIDWEDWRPV WVRNWQDKDV YRRLSRQLVA SRHPDWPPDR IVKQAQYEFE 180
FAAQQFMLET LRYVKAVRPR HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNDQLAW 240
LWAESTALFP SVYLDETLAS SRHGRNFVSF RVQEALRVAR THHANHALPV YVFTRPTYSR 300
RLTGLSEMDL ISTIGESAAL GAAGVILWGD AGYTTSTETC QYLKDYLTRL LVPYVVNVSW 360
ATQYCSRAQC HGHGRCVRRN PSASTFLHLS TNSFRLVPGH APGEPQLRPV GELSWADIDH 420
LQTHFRCQCY LGWSGEQCQW DHRQAAGGAS EAWAGSHLTS LLALAALAFT WTL 473 
Gene Ontology
 GO:0031362; C:anchored to external side of plasma membrane; IDA:UniProtKB.
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0030139; C:endocytic vesicle; IDA:BHF-UCL.
 GO:0005783; C:endoplasmic reticulum; NAS:UniProtKB.
 GO:0000139; C:Golgi membrane; ISS:UniProtKB.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0005902; C:microvillus; IDA:BHF-UCL.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005540; F:hyaluronic acid binding; IDA:UniProtKB.
 GO:0033906; F:hyaluronoglucuronidase activity; IDA:UniProtKB.
 GO:0004415; F:hyalurononglucosaminidase activity; IDA:UniProtKB.
 GO:0030294; F:receptor signaling protein tyrosine kinase inhibitor activity; IDA:UniProtKB.
 GO:0050431; F:transforming growth factor beta binding; ISS:BHF-UCL.
 GO:0001618; F:viral receptor activity; IDA:UniProtKB.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0051216; P:cartilage development; IEP:UniProtKB.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IDA:UniProtKB.
 GO:0071347; P:cellular response to interleukin-1; IDA:UniProtKB.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:BHF-UCL.
 GO:0071356; P:cellular response to tumor necrosis factor; IEP:UniProtKB.
 GO:0071493; P:cellular response to UV-B; IDA:UniProtKB.
 GO:0051607; P:defense response to virus; IEA:Compara.
 GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Compara.
 GO:0030214; P:hyaluronan catabolic process; IDA:UniProtKB.
 GO:0001822; P:kidney development; ISS:UniProtKB.
 GO:0042117; P:monocyte activation; IDA:UniProtKB.
 GO:0010259; P:multicellular organismal aging; IEA:Compara.
 GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0010764; P:negative regulation of fibroblast migration; IDA:UniProtKB.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; IDA:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISS:BHF-UCL.
 GO:0050729; P:positive regulation of inflammatory response; IDA:UniProtKB.
 GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB.
 GO:2000484; P:positive regulation of interleukin-8 secretion; IDA:UniProtKB.
 GO:0042307; P:positive regulation of protein import into nucleus; ISS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.
 GO:0070295; P:renal water absorption; ISS:UniProtKB.
 GO:0046677; P:response to antibiotic; IEP:UniProtKB.
 GO:0000302; P:response to reactive oxygen species; IDA:UniProtKB.
 GO:0048705; P:skeletal system morphogenesis; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0019087; P:transformation of host cell by virus; IDA:UniProtKB.
 GO:0019064; P:viral entry into host cell via membrane fusion with the plasma membrane; IDA:UniProtKB. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR000742; EG-like_dom.
 IPR017853; Glycoside_hydrolase_SF.
 IPR018155; Hyaluronidase. 
Pfam
 PF01630; Glyco_hydro_56 
SMART
 SM00181; EGF 
PROSITE
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3 
PRINTS
 PR00846; GLHYDRLASE56.