CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007554
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldo-keto reductase family 1 member C3 
Protein Synonyms/Alias
 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; Chlordecone reductase homolog HAKRb; Dihydrodiol dehydrogenase 3; DD-3; DD3; Dihydrodiol dehydrogenase type I; HA1753; Indanol dehydrogenase; Prostaglandin F synthase; PGFS; Testosterone 17-beta-dehydrogenase 5; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase 
Gene Name
 AKR1C3 
Gene Synonyms/Alias
 DDH1; HSD17B5; KIAA0119; PGFS 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
209LLDFCKSKDIVLVAYacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. 
Sequence Annotation
 NP_BIND 13 22 NADP (Potential).
 NP_BIND 217 280 NADP (By similarity).
 ACT_SITE 55 55 Proton donor (By similarity).
 BINDING 117 117 Substrate (By similarity).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; NAD; NADP; Oxidoreductase; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 323 AA 
Protein Sequence
MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ 60
VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM 120
SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP 180
GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV 240
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD 300
RNLHYFNSDS FASHPNYPYS DEY 323 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0047020; F:15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; IDA:UniProtKB.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:UniProtKB.
 GO:0047026; F:androsterone dehydrogenase (A-specific) activity; IEA:EC.
 GO:0047023; F:androsterone dehydrogenase activity; IDA:UniProtKB.
 GO:0047787; F:delta4-3-oxosteroid 5beta-reductase activity; IDA:UniProtKB.
 GO:0035410; F:dihydrotestosterone 17-beta-dehydrogenase activity; IDA:UniProtKB.
 GO:0045550; F:geranylgeranyl reductase activity; IDA:UniProtKB.
 GO:0047718; F:indanol dehydrogenase activity; IEA:EC.
 GO:0045703; F:ketoreductase activity; IDA:UniProtKB.
 GO:0047086; F:ketosteroid monooxygenase activity; IDA:UniProtKB.
 GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IDA:UniProtKB.
 GO:0018636; F:phenanthrene 9,10-monooxygenase activity; IDA:UniProtKB.
 GO:0036131; F:prostaglandin D2 11-ketoreductase activity; IEA:EC.
 GO:0004958; F:prostaglandin F receptor activity; IDA:UniProtKB.
 GO:0047017; F:prostaglandin-F synthase activity; IEA:EC.
 GO:0001758; F:retinal dehydrogenase activity; IDA:UniProtKB.
 GO:0004745; F:retinol dehydrogenase activity; IDA:UniProtKB.
 GO:0047045; F:testosterone 17-beta-dehydrogenase (NADP+) activity; IEA:EC.
 GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IEA:EC.
 GO:0047115; F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; IEA:EC.
 GO:0071276; P:cellular response to cadmium ion; IDA:UniProtKB.
 GO:0071277; P:cellular response to calcium ion; IDA:UniProtKB.
 GO:0071384; P:cellular response to corticosteroid stimulus; IDA:UniProtKB.
 GO:0071395; P:cellular response to jasmonic acid stimulus; IDA:UniProtKB.
 GO:0071379; P:cellular response to prostaglandin stimulus; IDA:UniProtKB.
 GO:0034614; P:cellular response to reactive oxygen species; IDA:UniProtKB.
 GO:0009267; P:cellular response to starvation; IEP:UniProtKB.
 GO:0019371; P:cyclooxygenase pathway; TAS:Reactome.
 GO:0044597; P:daunorubicin metabolic process; IMP:UniProtKB.
 GO:0044598; P:doxorubicin metabolic process; IMP:UniProtKB.
 GO:0016488; P:farnesol catabolic process; IDA:UniProtKB.
 GO:0030216; P:keratinocyte differentiation; IEP:UniProtKB.
 GO:0008584; P:male gonad development; IEP:UniProtKB.
 GO:0044259; P:multicellular organismal macromolecule metabolic process; IEP:UniProtKB.
 GO:1900053; P:negative regulation of retinoic acid biosynthetic process; IDA:UniProtKB.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:2000353; P:positive regulation of endothelial cell apoptotic process; IDA:UniProtKB.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:UniProtKB.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
 GO:0042448; P:progesterone metabolic process; IDA:UniProtKB.
 GO:0000060; P:protein import into nucleus, translocation; IDA:UniProtKB.
 GO:0048385; P:regulation of retinoic acid receptor signaling pathway; IDA:UniProtKB.
 GO:2000224; P:regulation of testosterone biosynthetic process; IMP:UniProtKB.
 GO:0070293; P:renal absorption; NAS:UniProtKB.
 GO:0007584; P:response to nutrient; IEP:UniProtKB.
 GO:0042574; P:retinal metabolic process; IDA:UniProtKB.
 GO:0061370; P:testosterone biosynthetic process; IMP:UniProtKB. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.