CPLM-011425

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-011425

UniProt Accession

GABP1_HUMAN; Q06547; A8IE52; Q06545; Q12940; Q12941; Q12942; Q8IYD0

Genbank Protein ID

D13316; D13317; U13045; U13046; U13047; U13048; EU159454; BT006652; CH471082; BC016910; BC036080; BC050702

Genbank Nucleotide ID

BAA02573.1; BAA02574.1; AAA65707.1; AAA65708.1; AAA65709.1; AAA65710.1; ABV90874.1; AAP35298.1; EAW77395.1; AAH16910.1; AAH36080.1; AAH50702.1

Protein Name

GA-binding protein subunit beta-1

Protein Synonyms/Alias

GABP subunit beta-1; GABPB-1; GABP subunit beta-2; GABPB-2; Nuclear respiratory factor 2; Transcription factor E4TF1-47; Transcription factor E4TF1-53

Gene Name

GABPB1

Gene Synonyms/Alias

E4TF1B; GABPB; GABPB2

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
9	SLVDLGKKLLEAARA	ubiquitination	[1]

Reference

[1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]

Functional Description

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Sequence Annotation

REPEAT 5 34 ANK 1.
REPEAT 37 66 ANK 2.
REPEAT 70 99 ANK 3.
REPEAT 103 132 ANK 4.
REPEAT 136 166 ANK 5.
REGION 258 327 Transcription activation and HCFC1

Keyword

Alternative splicing; ANK repeat; Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

395 AA

Protein Sequence

MSLVDLGKKL LEAARAGQDD EVRILMANGA PFTTDWLGTS PLHLAAQYGH YSTTEVLLRA 60
GVSRDARTKV DRTPLHMAAS EGHASIVEVL LKHGADVNAK DMLKMTALHW ATEHNHQEVV 120
ELLIKYGADV HTQSKFCKTA FDISIDNGNE DLAEILQIAM QNQINTNPES PDTVTIHAAT 180
PQFIIGPGGV VNLTDETGVS AVQFGNSSTS VLATLAALAE ASAPLSNSSE TPVVATEEVV 240
TAESVDGAIQ QVVSSGGQQV ITIVTDGIQL GNLHSIPTSG IGQPIIVTMP DGQQVLTVPA 300
TDIAEETVIS EEPPAKRQCI EIIENRVESA EIEVRSLLPG VLCRSHPK 348

Gene Ontology

GO:0005634; C:nucleus; IDA:MGI.
GO:0046982; F:protein heterodimerization activity; IDA:MGI.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

Interpro

IPR002110; Ankyrin_rpt.
IPR020683; Ankyrin_rpt-contain_dom.

Pfam

PF00023; Ank

SMART

SM00248; ANK

PROSITE

PS50297; ANK_REP_REGION
PS50088; ANK_REPEAT

PRINTS

PR01415; ANKYRIN.