UniProt Accession

 RASK_MOUSE; P32883; P04200; P08643 

Genbank Protein ID

 X02452; X02453; X02454; X02456; X02455; BC004642; BC010202; K01927; X00485 

Genbank Nucleotide ID

 CAA26295.1; CAA26295.1; CAA26295.1; CAA26295.1; CAA26296.1; AAH04642.1; AAH10202.1; AAA40037.1; CAA25160.1 

Protein Name

 GTPase KRas 

Protein Synonyms/Alias

 K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; GTPase KRas, N-terminally processed 

Gene Name

 Kras 

Gene Synonyms/Alias

 Kras2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
117	PMVLVGNKCDLPSRT	ubiquitination	[1]
128	PSRTVDTKQAQELAR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. 

Sequence Annotation

 NP_BIND 10 17 GTP.
 NP_BIND 57 61 GTP.
 NP_BIND 116 119 GTP.
 REGION 166 185 Hypervariable region.
 MOTIF 32 40 Effector region.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylthreonine; in GTPase KRas, N-
 MOD_RES 104 104 N6-acetyllysine (By similarity).
 MOD_RES 186 186 Cysteine methyl ester; in isoform 2A (By
 LIPID 180 180 S-palmitoyl cysteine.
 LIPID 186 186 S-farnesyl cysteine; in isoform 2A (By  

Keyword

 Acetylation; Alternative splicing; Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Prenylation; Proto-oncogene; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IGI:MGI.
 GO:0030036; P:actin cytoskeleton organization; IGI:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IGI:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IGI:MGI.
 GO:0035022; P:positive regulation of Rac protein signal transduction; IGI:MGI.
 GO:0007265; P:Ras protein signal transduction; IGI:MGI.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IGI:MGI.
 GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:MGI.
 GO:0051146; P:striated muscle cell differentiation; IGI:MGI.
 GO:0008542; P:visual learning; IGI:MGI. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.