UniProt Accession

 WTM1_YEAST; Q12363; D6W2T4; O00041 

Genbank Protein ID

 AF001451; X92441; Z75138; AY693156; BK006948 

Genbank Nucleotide ID

 AAB66316.1; CAA63193.1; CAA99450.1; AAT93175.1; DAA11000.1 

Protein Name

 Transcriptional modulator WTM1 

Protein Synonyms/Alias

  

Gene Name

 WTM1 

Gene Synonyms/Alias

 YOR230W; YOR50-20 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
23	HISSLRPKFVSRVDN	acetylation	[1]
48	SNVVVPDKKNNTLTS	acetylation	[1]
256	WDTRTSDKPIWVLGE	acetylation	[1]
384	ATEESQTKSLRFLHK	acetylation	[1]
384	ATEESQTKSLRFLHK	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Transcriptional modulator with roles in meiotic regulation and silencing. Acts either as an adapter to facilitate nuclear import by KAP122 of the RNR2-RNR4 herodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR); or as an anchor to retain RNR2- RNR4 in the nucleus. 

Sequence Annotation

 REPEAT 103 144 WD 1.
 REPEAT 221 259 WD 2.
 REPEAT 264 304 WD 3.
 REPEAT 326 366 WD 4.
 MOD_RES 187 187 Phosphothreonine.
 MOD_RES 200 200 Phosphoserine.
 MOD_RES 370 370 Phosphothreonine.
 MOD_RES 406 406 Phosphothreonine.  

Keyword

 Complete proteome; Cytoplasm; Meiosis; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 437 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0003714; F:transcription corepressor activity; IDA:SGD.
 GO:0051457; P:maintenance of protein location in nucleus; IMP:SGD.
 GO:0061186; P:negative regulation of chromatin silencing at silent mating-type cassette; IGI:SGD.
 GO:0031939; P:negative regulation of chromatin silencing at telomere; IGI:SGD.
 GO:0010674; P:negative regulation of transcription from RNA polymerase II promoter during meiosis; IGI:SGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0006606; P:protein import into nucleus; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS