CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015005
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ornithine aminotransferase 
Protein Synonyms/Alias
 Ornithine--oxo-acid aminotransferase 
Gene Name
 OAT 
Gene Synonyms/Alias
 PFF0435w 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
33DPIPVVLKRGKGVFVacetylation[1]
225GVASLCKKYNVLFVAacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
 The enzyme has a very narrow substrate specificity and can only catalyze the transamination of alpha-ketoglutarate with ornithine or N-acetylornithine and of glutamate-5-semialdehyde with glutamate and alanine. 
Sequence Annotation
 MOD_RES 262 262 N6-(pyridoxal phosphate)lysine (By  
Keyword
 3D-structure; Aminotransferase; Complete proteome; Cytoplasm; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 414 AA 
Protein Sequence
MDFVKELKSS QDYMNNELTY GAHNYDPIPV VLKRGKGVFV YDIEDRRYYD FLSAYSSVNQ 60
GHCHPDILNA MINQAKKLTI CSRAFFSDSL GVCERYLTNL FGYDKVLMMN TGAEASETAY 120
KLCRKWGYEV KKIPENSAKI IVCNNNFSGR TLGCVSASTD KKCKNNFGPF VPNFLKVPYD 180
DLEALEKELQ DPNVCAFIVE PVQGEAGVIV PSDSYFPGVA SLCKKYNVLF VADEVQTGLG 240
RTGKLLCTHH YGVKPDVILL GKALSGGHYP ISAILANDDV MLVLKPGEHG STYGGNPLAA 300
AICVEALKVL INEKLCENAD KLGAPFLQNL KEQLKDSKVV REVRGKGLLC AIEFKNDLVN 360
VWDICLKFKE NGLITRSVHD KTVRLTPPLC ITKEQLDECT EIIVKTVKFF DDNL 414 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004587; F:ornithine-oxo-acid transaminase activity; TAS:GeneDB_Pfalciparum.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006591; P:ornithine metabolic process; TAS:GeneDB_Pfalciparum. 
Interpro
 IPR005814; Aminotrans_3.
 IPR010164; Orn_aminotrans.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS