CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023480
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aryl hydrocarbon receptor nuclear translocator-like protein 1 
Protein Synonyms/Alias
 Arnt3; Brain and muscle ARNT-like 1 
Gene Name
 Arntl 
Gene Synonyms/Alias
 Bmal1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
259RSFFCRMKCNRPSVKsumoylation[1]
500GTRAGAGKIGRMIAEacetylation[2]
Reference
 [1] Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex.
 Lee J, Lee Y, Lee MJ, Park E, Kang SH, Chung CH, Lee KH, Kim K.
 Mol Cell Biol. 2008 Oct;28(19):6056-65. [PMID: 18644859]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 ARNTL-CLOCK heterodimers activate E-box element (5'- CACGTG-3') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins. 
Sequence Annotation
 DOMAIN 79 132 bHLH.
 DOMAIN 150 222 PAS 1.
 DOMAIN 333 403 PAS 2.
 DOMAIN 408 451 PAC.
 MOD_RES 544 544 N6-acetyllysine.
 CROSSLNK 266 266 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Acetylation; Activator; Alternative splicing; Biological rhythms; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 632 AA 
Protein Sequence
MADQRMDISS TISDFMSPGP TDLLSGSLGT SGVDCNRKRK GSATDYQLDD FAFEESMDTD 60
KDDPHGRLEY AEHQGRIKNA REAHSQIEKR RRDKMNSFID ELASLVPTCN AMSRKLDKLT 120
VLRMAVQHMK TLRGATNPYT EANYKPTFLS DDELKHLILR AADGFLFVVG CDRGKILFVS 180
ESVFKILNYS QNDLIGQSLF DYLHPKDIAK VKEQLSSSDT APRERLIDAK TGLPVKTDIT 240
PGPSRLCSGA RRSFFCRMKC NRPSVKVEDK DFASTCSKKK DRKSFCTIHS TGYLKSWPPT 300
KMGLDEDNEP DNEGCNLSCL VAIGRLHSHM VPQPANGEIR VKSMEYVSRH AIDGKFVFVD 360
QRATAILAYL PQELLGTSCY EYFHQDDIGH LAECHRQVLQ TREKITTNCY KFKIKDGSFI 420
TLRSRWFSFM NPWTKEVEYI VSTNTVVLAN VLEGGDPTFP QLTAPPHSMD SMLPSGEGGP 480
KRTHPTVPGI PGGTRAGAGK IGRMIAEEIM EIHRIRGSSP SSCGSSPLNI TSTPPPDASS 540
PGGKKILNGG TPDIPSTGLL PGQAQETPGY PYSDSSSILG ENPHIGIDMI DNDQGSSSPS 600
NDEAAMAVIM SLLEADAGLG GPVDFSDLPW PL 632 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016604; C:nuclear body; IDA:MGI.
 GO:0005667; C:transcription factor complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IPI:MGI.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IC:BHF-UCL.
 GO:0001190; F:RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; IDA:BHF-UCL.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0008134; F:transcription factor binding; ISA:MGI.
 GO:0032922; P:circadian regulation of gene expression; IDA:UniProtKB.
 GO:0000060; P:protein import into nucleus, translocation; IDA:MGI.
 GO:0042176; P:regulation of protein catabolic process; IDA:MGI. 
Interpro
 IPR011598; bHLH_dom.
 IPR001067; Nuc_translocat.
 IPR001610; PAC.
 IPR000014; PAS.
 IPR013767; PAS_fold.
 IPR013655; PAS_fold_3. 
Pfam
 PF00010; HLH
 PF00989; PAS
 PF08447; PAS_3 
SMART
 SM00353; HLH
 SM00086; PAC
 SM00091; PAS 
PROSITE
 PS50888; BHLH
 PS50113; PAC
 PS50112; PAS 
PRINTS
 PR00785; NCTRNSLOCATR.