CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016094
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 
Protein Synonyms/Alias
 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-beta 
Gene Name
 Pip4k2b 
Gene Synonyms/Alias
 Pip5k2b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
150YDRRFVIKTVSSEDVacetylation[1, 2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (By similarity). 
Sequence Annotation
 DOMAIN 38 415 PIPK.
 MOD_RES 150 150 N6-acetyllysine (By similarity).
 MOD_RES 326 326 Phosphoserine (By similarity).  
Keyword
 Acetylation; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transferase; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 416 AA 
Protein Sequence
MSSNCTSTTA VAVAPLSASK TKTKKKHFVC QKVKLFRASE PILSVLMWGV NHTINELSNV 60
PVPVMLMPDD FKAYSKIKVD NHLFNKENLP SRFKFKEYCP MVFRNLRERF GIDDQDYQNS 120
VTRSAPINSD SQGRCGTRFL TTYDRRFVIK TVSSEDVAEM HNILKKYHQF IVECHGNTLL 180
PQFLGMYRLT VDGVETYMVV TRNVFSHRLT VHRKYDLKGS TVAREASDKE KAKDLPTFKD 240
NDFLNEGQKL HVGEESKKNF LEKLKRDVEF LAQLKIMDYS LLVGIHDVDR AEQEEMEVEE 300
RAEEEECEND GVGGSLLCSY GTPPDSPGNL LSFPRFFGPG EFDPSVDVYA MKSHESAPKK 360
EVYFMAIIDI LTPYDAKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFNEF MSNILT 416 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; ISO:MGI.
 GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR023610; PInositol-4-P-5-kinase.
 IPR027483; PInositol-4-P-5-kinase_C.
 IPR002498; PInositol-4-P-5-kinase_core.
 IPR027484; PInositol-4-P-5-kinase_N.
 IPR016034; PInositol-4P-5-kinase_core_sub. 
Pfam
 PF01504; PIP5K 
SMART
 SM00330; PIPKc 
PROSITE
 PS51455; PIPK 
PRINTS