UniProt Accession

 1C12_HUMAN; P30508; O02863; O19652; O62882; O78062; O78166; O78211; O78214; P30509; Q29768; Q31627; Q860R1; Q860R2; Q99528; Q9GIK4; Q9TPS4; Q9UM32; Q9UM33 

Genbank Protein ID

 M21963; M28172; X70856; X70857; D64152; D83741; AH008326; U06695; U06696; X82122; AJ420248; D64146; Y11843; X99704; AH006134; AH006135; Z83247; Z80228; AJ249163; AJ249164; AJ304496; AJ550622; AJ550623 

Genbank Nucleotide ID

 AAA59847.1; AAA59670.1; CAA50209.1; CAA50210.1; BAA19537.1; BAA32615.1; AAF04581.1; AAA92995.1; AAA92996.1; CAA57634.1; CAD12433.1; BAA19532.1; CAA72592.1; CAA68035.1; AAC17724.1; AAC17725.1; CAB05845.1; CAB02409.1; CAB53538.1; CAB53539.1; CAC19018.1; CAD79471.1; CAD79472.1 

Protein Name

 HLA class I histocompatibility antigen, Cw-12 alpha chain 

Protein Synonyms/Alias

 MHC class I antigen Cw*12 

Gene Name

 HLA-C 

Gene Synonyms/Alias

 HLAC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
145	DQSAYDGKDYIALNE	ubiquitination	[1, 2]
210	LQRAEHPKTHVTHHP	ubiquitination	[3]
267	AGDGTFQKWAAVVVP	ubiquitination	[1, 2]
365	DESLIACKA******	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system. 

Sequence Annotation

 DOMAIN 209 297 Ig-like C1-type.
 REGION 25 114 Alpha-1.
 REGION 115 206 Alpha-2.
 REGION 207 298 Alpha-3.
 REGION 299 308 Connecting peptide.
 CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
 DISULFID 125 188 By similarity.
 DISULFID 227 283 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; Membrane; MHC I; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 366 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; TAS:Reactome.
 GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.