CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin-binding protein H 
Protein Synonyms/Alias
 MyBP-H; H-protein 
Gene Name
 MYBPH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
427MEIQGNPKYRALSEQubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Binds to myosin; probably involved in interaction with thick myofilaments in the A-band. 
Sequence Annotation
 DOMAIN 71 163 Fibronectin type-III 1.
 DOMAIN 172 260 Ig-like C2-type 1.
 DOMAIN 267 358 Fibronectin type-III 2.
 DOMAIN 382 466 Ig-like C2-type 2.  
Keyword
 Cell adhesion; Complete proteome; Immunoglobulin domain; Muscle protein; Polymorphism; Reference proteome; Repeat; Thick filament. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 477 AA 
Protein Sequence
MMEKNTSEGP ACSPEETASE SAKVPTAEPP GEVAVSESTR EEQVPKPQAP APQAPTASTA 60
TKPAPPSEDV PSAPLLLTLD DVSSSSVTVS WEPPERLGRL GLQGYVLELC REGASEWVPV 120
SARPMMVTQQ TVRNLALGDK FLLRVSAVSS AGAGPPAMLD QPIHIRENIE APKIRVPRHL 180
RQTYIRQVGE TVNLQIPFQG KPKPQATWTH NGHALDSQRV SMRTGDQDSI LFIRSAQRSD 240
SGRYELTVRV EDLEAKAVID ILVIEKPGPP SSIRLLDVWG CNAALQWTPP QDTGNTELLG 300
YMVQKADKKT GQWFTVLERY HPTTCTISDL IIGNSYSFRV FSENLCGLST SATVTKELAH 360
IQKADIAAKP KGFIERDFSE APSFTQPLAD HTSTPGYSTQ LFCSVRASPK PKIIWMKNKM 420
EIQGNPKYRA LSEQGVCTLE IRKPSPFDSG VYTCKAINVL GEASVDCRLE VKASAAH 477 
Gene Ontology
 GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
 GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0006942; P:regulation of striated muscle contraction; TAS:ProtInc. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS