UniProt Accession

 CO7C_CONMA; P37300 

Genbank Protein ID

 S40826 

Genbank Nucleotide ID

 AAB22674.1 

Protein Name

 Omega-conotoxin MVIIC 

Protein Synonyms/Alias

 SNX-230 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Conus magus (Magus cone) (Magician's cone snail) 

NCBI Taxa ID

 6492 

Lysine Modification

Position	Peptide	Type	References
4	****TRCKGKGAPCR	acetylation	[1]
6	**TRCKGKGAPCRKT	acetylation	[1]
12	GKGAPCRKTMYDCCS	acetylation	[1]
27	GSCGRRGKCG*****	acetylation	[1]

Reference

 [1] Oxidative folding of omega-conotoxin MVIIC: effects of temperature and salt.
 Kubo S, Chino N, Kimura T, Sakakibara S.
 Biopolymers. 1996 Jun;38(6):733-44. [PMID: 8652794] 

Functional Description

 Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A). 

Sequence Annotation

 MOD_RES 28 28 Cysteine amide.
 DISULFID 3 18
 DISULFID 10 22
 DISULFID 17 28  

Keyword

 3D-structure; Amidation; Calcium channel inhibitor; Disulfide bond; Ion channel impairing toxin; Knottin; Neurotoxin; Presynaptic neurotoxin; Secreted; Toxin. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 29 AA 

Protein Sequence

Gene Ontology

 GO:0072556; C:other organism presynaptic membrane; IEA:UniProtKB-KW.
 GO:0019855; F:calcium channel inhibitor activity; IEA:UniProtKB-KW.
 GO:0009405; P:pathogenesis; IEA:InterPro. 

Interpro

 IPR012321; Conotoxin_omega-typ_CS. 

Pfam

  

SMART

  

PROSITE

 PS60004; OMEGA_CONOTOXIN 

PRINTS