UniProt Accession

 RXRB_HUMAN; P28702; P28703; Q59G65; Q5JP92; Q5STQ1 

Genbank Protein ID

 M84820; X63522; AF065396; AF120161; HQ709179; AB209244; AL031228; AL844527; CR936877; CR759733; CR354565; AL645940; AL662824; BC001167; X66424 

Genbank Nucleotide ID

 AAA60293.1; CAA45087.1; AAC18599.1; AAD13794.1; ADZ17386.1; BAD92481.1; CAA20239.1; CAI41836.2; CAQ09065.1; CAQ10299.1; CAQ11083.1; AAH01167.1 

Protein Name

 Retinoic acid receptor RXR-beta 

Protein Synonyms/Alias

 Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta 

Gene Name

 RXRB 

Gene Synonyms/Alias

 NR2B2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
427	VLTELVSKMRDMRMD	ubiquitination	[1]
435	MRDMRMDKTELGCLR	ubiquitination	[1]
452	ILFNPDAKGLSNPSE	ubiquitination	[2, 3, 4]
488	EQQGRFAKLLLRLPA	ubiquitination	[2, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA). 

Sequence Annotation

 DNA_BIND 205 270 Nuclear receptor.
 ZN_FING 205 225 NR C4-type.
 ZN_FING 241 265 NR C4-type.
 REGION 1 204 Modulating (By similarity).
 REGION 271 330 Hinge.
 REGION 331 533 Ligand-binding (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 533 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004886; F:9-cis retinoic acid receptor activity; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 

Interpro

 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR000003; Retinoid-X_rcpt/HNF4.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00104; Hormone_recep
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR00545; RETINOIDXR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.