CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000576
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HCLS1-associated protein X-1 
Protein Synonyms/Alias
 HS1-associating protein X-1; HAX-1; HS1-binding protein 1; HSP1BP-1 
Gene Name
 Hax1 
Gene Synonyms/Alias
 Hs1bp1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
132TLRDSMLKYPDSHQPubiquitination[1]
206PLLQPQPKSYFKSISubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools (By similarity). 
Sequence Annotation
 REGION 2 45 Required for localization in mitochondria
 REGION 115 280 Involved in HCLS1 binding (By
 REGION 176 207 Involved in CASP9 binding (By
 REGION 177 248 Involved in GNA13 binding (By
 REGION 184 280 Required for localization in sarcoplasmic
 REGION 185 280 Involved in PKD2 binding.
 REGION 204 246 Involved in ATP2A2 binding (By
 REGION 204 226 Involved in PLN binding (By similarity).
 REGION 271 280 Required for ITGB6 binding (By
 MOD_RES 2 2 N-acetylserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; Membrane; Mitochondrion; Nucleus; Reference proteome; Sarcoplasmic reticulum. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 280 AA 
Protein Sequence
MSVFDLFRGF FGFPGPRSHR DPFFGGMTRD DDDDDDDDDE AEEDRGAWGR ESYAFDGSQP 60
PEEFGFSFSP RGGMRFHGNF GFDDLVRDFN SIFSEMGAWT LPSHSPELPG PESETPGERL 120
REGQTLRDSM LKYPDSHQPR IFEGVLESHA KPESPKPAPD WGSQGPFHRL DDTWPVSPHS 180
RAKEDKDLDS QVSQEGLGPL LQPQPKSYFK SISVTKITKP DGTVEERRTV VDSEGRRETT 240
VTHQEAHDSS RSDPDSQRSS ALDDPFSILD LLLGRWFRSR 280 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:BHF-UCL.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IDA:BHF-UCL.
 GO:0030027; C:lamellipodium; IDA:BHF-UCL.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:MGI.
 GO:0071345; P:cellular response to cytokine stimulus; IEA:Compara.
 GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Compara.
 GO:0030854; P:positive regulation of granulocyte differentiation; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030833; P:regulation of actin filament polymerization; IEA:Compara. 
Interpro
 IPR017248; HS1--assoc_X-1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS