Tag | Content |
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CPLM ID | CPLM-022739 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pericentriolar material 1 protein |
Protein Synonyms/Alias | PCM-1; mPCM-1 |
Gene Name | Pcm1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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259 | SYMKFLQKILARENE | ubiquitination | [1] | 432 | SEHLPDEKVQLFSKM | ubiquitination | [1] | 438 | EKVQLFSKMRVLQEK | ubiquitination | [1] | 1112 | QNNVQRLKQMLTELM | ubiquitination | [1] | 1217 | TEYMAFPKPFESSSS | ubiquitination | [1] | 1229 | SSSLGAEKQRNQKQP | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins probably including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Probably involved in the biogenesis of cilia. |
Sequence Annotation | MOD_RES 65 65 Phosphoserine. MOD_RES 68 68 Phosphoserine (By similarity). MOD_RES 69 69 Phosphoserine. MOD_RES 93 93 Phosphoserine (By similarity). MOD_RES 110 110 Phosphoserine (By similarity). MOD_RES 399 399 N6-acetyllysine (By similarity). MOD_RES 859 859 Phosphoserine (By similarity). MOD_RES 864 864 Phosphoserine. MOD_RES 957 957 Phosphoserine (By similarity). MOD_RES 1182 1182 Phosphoserine (By similarity). MOD_RES 1228 1228 Phosphoserine (By similarity). MOD_RES 1254 1254 Phosphoserine (By similarity). MOD_RES 1257 1257 Phosphoserine (By similarity). MOD_RES 1260 1260 Phosphoserine (By similarity). MOD_RES 1287 1287 Phosphoserine. MOD_RES 1432 1432 Phosphoserine. MOD_RES 1434 1434 Phosphoserine. MOD_RES 1654 1654 Phosphoserine. MOD_RES 1695 1695 Phosphoserine (By similarity). MOD_RES 1729 1729 Phosphoserine. MOD_RES 1766 1766 Phosphoserine. MOD_RES 1769 1769 Phosphoserine. MOD_RES 1777 1777 Phosphoserine. MOD_RES 1959 1959 Phosphoserine (By similarity). MOD_RES 1978 1978 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2025 AA |
Protein Sequence | MATGGGPFEE VMHDQDLPNW SNDSVDDRLN NMEWGGQQKK ANRSSEKNKK KFGVASDKRV 60 TNAISPESSP GVGRRRTKIP HTFPHSRYMT QMSVPEQAEL EKLKQRINFS DLDQRSIGSD 120 SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDATASL PKREMTTSAQ CKELFASALS 180 NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT 240 HLIEHLKEQE KSYMKFLQKI LARENEEEDV RTVDSAVGSG SVAESTSLNA DVQSEASDTT 300 ARDPQQEPME ETENLKKQHD LLKRMLQQQE QLRALQGRQA ALLALQHKAE QAIAVMDDSV 360 VTETTGSLSG VSITSELNEE LNDLIQRFHN QLRDSQPPAV PDNRRQAESL SLTREISQSR 420 NPSVSEHLPD EKVQLFSKMR VLQEKKQKMD KLLGELHNLR DQHLNNSSFV PSTSLQRSGD 480 KRSSTVALSA PVGFASAVNG EANSLISSVP CPATSLVSQN ESENEGHLNP AEKLQKLNEV 540 QKRLNELREL VHYYEQTSDM MTDAVNENTK DEETEESEYD SEHENSEPVT NIRNPQVAST 600 WNEVNTNSNT QCGSNNRDGR PVNSNCEINN RSAANIRALN MPPLDCRYNR EGEQRLHVAH 660 GEDEEEEVEE EGVSGASLSS RRSSLVDEAP EDEEFEQKIS RLMAAKEKLK QLQDLVAMVQ 720 DDDATQVVVP AASNLDDFYA AEEDIKQNSN NARENSNKID TGVNEKTREK FYEAKLQQQQ 780 RELKQLQEER KKLIEIQEKI QAVQKACPDL QLSATSISSG PTKKYLPAIT STPTVNENDS 840 STSKCVIDPE DSSVVDNELW SDMRRHEMLR EELRQRRKQL EALMAEHQRR QGLAETSSPV 900 AISLRSDGSE NLCTPQQSRT EKTMATWGGS TQCALDEEGD EDGYLSEGIV RTDEEEEEEQ 960 DASSNDNFPI YPPSMNQNSY NVKETKTRWK SNRPVSADGN YRPLAKTRQQ NISMQRQENL 1020 RWVSELSYIE EKEQWQEQIN QLKKQLDFSV NICQTLMQDQ QTLSCLLQTL LTGPYSVLPS 1080 NVASPQVHLI MHQLNQCYTQ LTWQQNNVQR LKQMLTELMR QQNQHPEKPR SKERGSSASH 1140 PSSPNLFCPF SFPTQPVNLF NLPGFTNFPS FAPGMNFSPL FPSNFGDFSQ NVSTPTEQQQ 1200 PLAQNPSGKT EYMAFPKPFE SSSSLGAEKQ RNQKQPEEEA ENTKTPWLYD QEGGVEKPFF 1260 KTGFTESVEK ATNSNRKNQP DTSRRRRQFD EESLESFSSM PDPIDPTTVT KTFKTRKASA 1320 QASLASKDKT PKSKSKKRNS TQLKSRVKNI GYESASVSST CEPCKNRNRH SAQTEEPVQA 1380 KLFSRKNHEQ LEKIIKYSRS AEISSETGSD FSMFEALRDT IYSEVATLIS QNESRPHFLI 1440 ELFHELQLLN TDYLRQRALY ALQDIVSRHI SESDEREGEN VKPVNSGTWV ASNSELTPSE 1500 SLVTTDDETF EKNFERETHK VSEQNDADNV SVMSVSSNFE PFATDDLGNT VIHLDQALAR 1560 MREYERMKTE TESHSNMRCT CRVIEDEDGA AAAATVSNSE ETPIIENHNS PQPISDVSAV 1620 PCPRIDTQQL DRQIKAIMKE VIPFLKEHMD EVCSSQLLTS VRRMVLTLTQ QNDESKEFVK 1680 FFHKQLGSIL QDSLAKFAGR KLKDCGEDLL VEISEVLFNE LAFFKLMQDL DNNSIAVKQR 1740 CKRKIEAAGV RQSYAKEAKR ILEGDHGSPA GEIDDEDKDK DETETVKQTQ TSEVYDAKGP 1800 KNVRSDVSDQ EEDEESERCP VSINLSKAES QALTNYGSGE DENEDEEMED FEESPVDIQT 1860 SLQANTETTE ENEHDSQILQ HDLEKTPEST NVPSDQEPTS KNDQDSSPVK PCYLNILENE 1920 QQLNSATHKD SLTTTDSSKQ PEPLPLPLAA SETLVPRVKE VKSAQETPES SLAGSPDTES 1980 PVLVNDYEAE SGNISQKSDE EDFVKVEDLP LKLTVYSEEE LRKKMIEEEQ KNHLSGEICE 2040 MQTEELAGNS QILKEPETVG AQSI 2064 |
Gene Ontology | GO:0034451; C:centriolar satellite; IDA:BHF-UCL. GO:0031965; C:nuclear membrane; IEA:Compara. GO:0000242; C:pericentriolar material; IDA:BHF-UCL. GO:0051297; P:centrosome organization; IEA:Compara. GO:0042384; P:cilium assembly; ISS:UniProtKB. GO:0022027; P:interkinetic nuclear migration; IMP:BHF-UCL. GO:0034454; P:microtubule anchoring at centrosome; IMP:MGI. GO:0050768; P:negative regulation of neurogenesis; IMP:BHF-UCL. GO:0097150; P:neuronal stem cell maintenance; IMP:MGI. GO:0071539; P:protein localization to centrosome; IMP:BHF-UCL. |
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