CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028490
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 GDH/6PGL endoplasmic bifunctional protein 
Protein Synonyms/Alias
  
Gene Name
 H6pd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
213RVDHYLGKQAVAQILacetylation[1]
213RVDHYLGKQAVAQILsuccinylation[1]
310QALRGLQKSSAILGQubiquitination[2]
432KPSLPTQKWKEVQDQacetylation[1, 3]
432KPSLPTQKWKEVQDQsuccinylation[1]
434SLPTQKWKEVQDQPGubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 797 AA 
Protein Sequence
MKHTGIWKML LAAMCLALLG CLQAQELKGH VSIILLGATG DLAKKYLWQG LFQLYLDEAG 60
KGHSFSFHGA ALTAPQQGQK LMDKVLESLS CPKDLVPSRC DELKGQFLQL SQYRQLKTVE 120
DYQTLNKDIE TQVQQDGLWE AGRIFYFSVP PFAYADIARN INSSCRPHPG AWLRVVFEKP 180
FGHDHLSAQQ LASELGSFFQ EEEMYRVDHY LGKQAVAQIL PFRDQNRKAL DGLWNRHHVE 240
RVEIILKETI DAEGRASFYE EYGVIRDTLQ NHLTEILTLV AMELPLNISS SAAVLQHKLW 300
AFQALRGLQK SSAILGQYQA YSGQVRRELQ KPDGFQSLTP TFAGVLVHID NLRWEGVPFI 360
LMSGKALDER VGYVRIVFKN RAYCTQSERH WVPEQSRCLP QQIIFYIGHG ELGHPAILVS 420
RNLFKPSLPT QKWKEVQDQP GLRLFGRPLS DYYAYRPVRE QDAYSTLLSH IFHCRKESFI 480
TTENLLASWV FWTPLLDSLA FEVPRPYPGG AENGQLLDFE FSGGQLTFSQ QQLEVLIPDL 540
GSVPKPSDFQ VLGARYRQSP LITAWPEELI SKLASDIEAA AVQAVRHFGK FHLALSGGSS 600
PIALFQQLAT GHYSFPWAHT HLWLVDERCV PLSDPDSNFQ GLQAHLLQHV RVPYYNIHPM 660
PVHLHQRLCA EEDQGAQTYA SEISALVANS SFDLVLLGMG TDGHTASLFP QSPTGLDGDQ 720
LVVLTESPFR PHQRMSLSLP LINRAKKVAV LVMGRTKREI TTLVSRVGHE PKKWPISGVV 780
PLSGQLVWYM DYEAFLG 797 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0017057; F:6-phosphogluconolactonase activity; IDA:MGI.
 GO:0030246; F:carbohydrate binding; IEA:Compara.
 GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IDA:MGI.
 GO:0050661; F:NADP binding; IEA:Compara.
 GO:0006098; P:pentose-phosphate shunt; IDA:MGI.
 GO:0097305; P:response to alcohol; IEA:Compara. 
Interpro
 IPR005900; 6-phosphogluconolactonase_DevB.
 IPR001282; G6P_DH.
 IPR019796; G6P_DH_AS.
 IPR022675; G6P_DH_C.
 IPR022674; G6P_DH_NAD-bd.
 IPR006148; Glc/Gal-6P_isomerase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02781; G6PD_C
 PF00479; G6PD_N
 PF01182; Glucosamine_iso 
SMART
  
PROSITE
 PS00069; G6P_DEHYDROGENASE 
PRINTS
 PR00079; G6PDHDRGNASE.