UniProt Accession

 SPS2_HUMAN; Q99611; Q9BUQ2 

Genbank Protein ID

 U43286; AC116348; BC002381; BC016643 

Genbank Nucleotide ID

 AAC50958.2; AAH02381.3; AAH16643.1 

Protein Name

 Selenide, water dikinase 2 

Protein Synonyms/Alias

 Selenium donor protein 2; Selenophosphate synthase 2 

Gene Name

 SEPHS2 

Gene Synonyms/Alias

 SPS2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
197	KVTPLMVKGFRDAAE	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Synthesizes selenophosphate from selenide and ATP. 

Sequence Annotation

 NP_BIND 319 325 ATP (Potential).
 ACT_SITE 60 60 Potential.  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Selenium; Selenocysteine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 448 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004756; F:selenide, water dikinase activity; NAS:UniProtKB.
 GO:0016260; P:selenocysteine biosynthetic process; NAS:UniProtKB. 

Interpro

 IPR010918; AIR_synth_C_dom.
 IPR000728; AIR_synth_N_dom.
 IPR016188; PurM_N-like.
 IPR004536; SelD. 

Pfam

 PF00586; AIRS
 PF02769; AIRS_C 

SMART

  

PROSITE

  

PRINTS