| Tag | Content |
|---|
| CPLM ID | CPLM-017883 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | OTU domain-containing protein 7A |
Protein Synonyms/Alias | Zinc finger protein Cezanne 2 |
Gene Name | Otud7a |
Gene Synonyms/Alias | Cezanne2; Otud7 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 525 | NKLGSFSKTLGIKLK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin (By similarity). |
Sequence Annotation | DOMAIN 201 377 OTU.
ZN_FING 884 919 A20-type.
REGION 170 413 TRAF-binding (By similarity).
REGION 185 452 Catalytic (By similarity).
MOTIF 497 512 Nuclear localization signal (Potential).
ACT_SITE 212 212 Nucleophile (By similarity).
ACT_SITE 370 370 Proton acceptor (By similarity). |
Keyword | Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 926 AA |
Protein Sequence | MVSSLLPNPP SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL 60
SDYEQLRQVH TANLPHVFNE GRCAKQAERE LPQPGHKVER PCLQRQDDIA QAEKRLSRGI 120
SHASSAIVSL ARSHVANECN NEQFPLEMPI YTFQLPDLSV YSEDFRSFIE RDLIEQATMV 180
ALEQAGRLNW WSTVCTSCKR LLPLATTGDG NCLLHAASLG MWGFHDRDLV LRKALYTMMR 240
TGAEREALKR RWRWQQTQQN KEEEWEREWT ELLKLASSEP RTHFSKNGSG TGGGVDNSED 300
PVYESLEEFH VFVLAHILRR PIVVVADTML RDSGGEAFAP IPFGGIYLPL EVPPNRCHCS 360
PLVLAYDQAH FSALVSMEQR DQQREQAVIP LTDSEHKLLP LHFAVDPGKD WEWGKDDNDN 420
ARLANLILSL EAKLNLLHSY MNVTWIRIPS ETRAPLAQPE SPTASAGEDV QSLAESLDSD 480
RDSVCSNSNS NNGKNGKDKE KEKQRKDKDK TRADSVANKL GSFSKTLGIK LKKNMGGLGG 540
LVHGKMGRAN SANGKNGDSA ERNKEKKSKS RKGSKEESGA SASTSPSEKT TPSPTDKASG 600
ASPADKGSGS RGDAWKYSTD VKLSLNILRA AMQGERKFIF AGLLLTSHRH QFHEEMIGYY 660
LTSAQERFSA EQEQRRRDAA AAAAAATATA TVKRPARRPE AEGAPGPERA SPGPTAAQPT 720
QLVLKLKERP SPGTGASARA ARAAGGAASP GPGGGARRAA PGTGGPTPGR SPPAPARQSV 780
IHVQAAARDE ACAPTVGALR PCATYPQQNR SLWSQSYSPA RSALRTVNTV ESLAPGGADA 840
PGPAEHKSQT YSNGFGAARD GLEFADADAP AARSNAECGR GGPGPAQRRC QRENCAFYGR 900
AETEHFCSYC YREELRRRRE ARAARP 926 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |