CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010346
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 
Protein Synonyms/Alias
 Polymyxin resistance protein PmrH; UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase; UDP-Ara4O aminotransferase; UDP-4-amino-4-deoxy-L-arabinose aminotransferase 
Gene Name
 arnB 
Gene Synonyms/Alias
 pmrH; yfbE; b2253; JW5372 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
164HAVGTYYKGRHIGAKacetylation[1]
207ARQLRMLKFHGLGVDacetylation[1]
235EVLTPGYKYNLTDINacetylation[1]
314DALMEALKERGIGTGacetylation[1]
331FRAAHTQKYYRERFPacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. 
Sequence Annotation
 MOD_RES 182 182 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Aminotransferase; Antibiotic resistance; Complete proteome; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Lipopolysaccharide biosynthesis; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 379 AA 
Protein Sequence
MSEFLPFSRP AMGVEELAAV KEVLESGWIT TGPKNQALEQ AFCQLTGNQH AIAVSSATAG 60
MHITLMALKI GKGDEVITPS LTWVSTLNMI SLLGATPVMV DVDRDTLMVT PEAIESAITP 120
RTKAIIPVHY AGAPADIDAI RAIGERYGIA VIEDAAHAVG TYYKGRHIGA KGTAIFSFHA 180
IKNITCAEGG LIVTDNENLA RQLRMLKFHG LGVDAYDRQT WGRAPQAEVL TPGYKYNLTD 240
INAAIALTQL VKLEHLNTRR REIAQQYQQA LAALPFQPLS LPAWPHVHAW HLFIIRVDEQ 300
RCGISRDALM EALKERGIGT GLHFRAAHTQ KYYRERFPTL SLPNTEWNSE RICSLPLFPD 360
MTTADADHVI TALQQLAGQ 379 
Gene Ontology
 GO:0005737; C:cytoplasm; NAS:EcoCyc.
 GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc.
 GO:0008483; F:transaminase activity; IDA:EcoCyc.
 GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. 
Interpro
 IPR022850; ArnB_NH2Trfase.
 IPR000653; DegT/StrS_aminotransferase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF01041; DegT_DnrJ_EryC1 
SMART
  
PROSITE
  
PRINTS