UniProt Accession

 NHEJ1_HUMAN; Q9H9Q4; B8ZZA4; Q4ZFW7; Q6IA64; Q96JS9 

Genbank Protein ID

 AJ972687; AK022672; CR457291; AC020575; AC068946; AC097468; BC008210; BC012732; BC030986 

Genbank Nucleotide ID

 CAI99410.1; BAB14168.1; CAG33572.1; AAX88921.1; AAH08210.2; AAH12732.1; AAH30986.1 

Protein Name

 Non-homologous end-joining factor 1 

Protein Synonyms/Alias

 Protein cernunnos; XRCC4-like factor 

Gene Name

 NHEJ1 

Gene Synonyms/Alias

 XLF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
180	TLIRDRLKTEPFEEN	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. 

Sequence Annotation

  

Keyword

 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; Disease mutation; DNA damage; DNA repair; DNA-binding; Nucleus; Polymorphism; Reference proteome; SCID. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0070419; C:nonhomologous end joining complex; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030183; P:B cell differentiation; IMP:UniProtKB.
 GO:0007417; P:central nervous system development; NAS:UniProtKB.
 GO:0006310; P:DNA recombination; IEA:InterPro.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:UniProtKB.
 GO:0051351; P:positive regulation of ligase activity; NAS:UniProtKB.
 GO:0010212; P:response to ionizing radiation; IDA:UniProtKB.
 GO:0030217; P:T cell differentiation; IMP:UniProtKB. 

Interpro

 IPR015381; XLF/Cernunnos.
 IPR009089; XRCC4_N. 

Pfam

 PF09302; XLF 

SMART

  

PROSITE

  

PRINTS