UniProt Accession

 SWC4_YEAST; P53201; D6VUD9 

Genbank Protein ID

 Z72787; AY692656; BK006941 

Genbank Nucleotide ID

 CAA96985.1; AAT92675.1; DAA08100.1 

Protein Name

 SWR1-complex protein 4 

Protein Synonyms/Alias

 ESA1-associated factor 2 

Gene Name

 SWC4 

Gene Synonyms/Alias

 EAF2; GOD1; YGR002C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
113	PKESPYSKFNQHLSI	acetylation	[1]
146	QKSVESEKNHNENFT	acetylation	[1]
345	QLQQLNVKKSEVKEN	acetylation	[2]
346	LQQLNVKKSEVKENL	acetylation	[2]
350	NVKKSEVKENLSPKK	acetylation	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591] 

Functional Description

 Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. 

Sequence Annotation

 DOMAIN 156 209 SANT.  

Keyword

 Activator; Chromatin regulator; Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 476 AA 

Protein Sequence

Gene Ontology

 GO:0035267; C:NuA4 histone acetyltransferase complex; IPI:SGD.
 GO:0000812; C:Swr1 complex; IDA:SGD.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; ISS:SGD.
 GO:0006281; P:DNA repair; IDA:SGD.
 GO:0034087; P:establishment of mitotic sister chromatid cohesion; IMP:SGD.
 GO:0016573; P:histone acetylation; IPI:SGD.
 GO:0043486; P:histone exchange; IPI:SGD.
 GO:0043968; P:histone H2A acetylation; IEA:InterPro.
 GO:0043967; P:histone H4 acetylation; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR027109; Swc4/Dmap1. 

Pfam

  

SMART

 SM00717; SANT 

PROSITE

 PS51293; SANT 

PRINTS