| Tag | Content |
|---|
| CPLM ID | CPLM-021361 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-box/LRR-repeat protein 15 |
Protein Synonyms/Alias | F-box only protein 37 |
Gene Name | FBXL15 |
Gene Synonyms/Alias | FBXO37 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 180 | LTACRQLKDEAIVYL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. |
Sequence Annotation | DOMAIN 19 66 F-box.
REPEAT 141 162 LRR 1.
REPEAT 167 188 LRR 2.
REPEAT 194 215 LRR 3.
REPEAT 220 241 LRR 4.
REPEAT 246 267 LRR 5.
REGION 113 269 Interaction with SMURF1. |
Keyword | Complete proteome; Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 300 AA |
Protein Sequence | MEPPMEPSGG EQEPGAVRFL DLPWEDVLLP HVLNRVPLRQ LLRLQRVSRA FRSLVQLHLA 60
GLRRFDAAQV GPQIPRAALA RLLRDAEGLQ ELALAPCHEW LSDEDLVPVL ARNPQLRSVA 120
LGGCGQLSRR ALGALAEGCP RLQRLSLAHC DWVDGLALRG LADRCPALEE LDLTACRQLK 180
DEAIVYLAQR RGAGLRSLSL AVNANVGDAA VQELARNCPE LHHLDLTGCL RVGSDGVRTL 240
AEYCPVLRSL RVRHCHHVAE SSLSRLRKRG VDIDVEPPLH QALVLLQDMA GFAPFVNLQV 300 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB. GO:0030282; P:bone mineralization; ISS:UniProtKB. GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB. GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:UniProtKB. GO:0030513; P:positive regulation of BMP signaling pathway; IMP:UniProtKB. GO:0016567; P:protein ubiquitination; IDA:UniProtKB. GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB. |
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