UniProt Accession

 AES_RAT; P63003; Q06195; Q3MIF3 

Genbank Protein ID

 L14462; BC101855 

Genbank Nucleotide ID

 AAC37639.1; AAI01856.1 

Protein Name

 Amino-terminal enhancer of split 

Protein Synonyms/Alias

 Amino enhancer of split; Protein ESP1; R-esp1; Protein GRG 

Gene Name

 Aes 

Gene Synonyms/Alias

 Esp1; Grg 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
54	CDKLASEKSEMQRHY	ubiquitination	[1]
112	LGAIERAKQVTAPEL	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state (By similarity). 

Sequence Annotation

 REGION 166 197 CCN domain.
 MOD_RES 196 196 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:RGD.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0031668; P:cellular response to extracellular stimulus; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IEA:Compara.
 GO:0060761; P:negative regulation of response to cytokine stimulus; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:2000210; P:positive regulation of anoikis; IEA:Compara.
 GO:0040008; P:regulation of growth; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0001501; P:skeletal system development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR005617; Groucho/TLE_N. 

Pfam

 PF03920; TLE_N 

SMART

  

PROSITE

  

PRINTS