CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001103
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein CBFA2T3 
Protein Synonyms/Alias
 MTG8-related protein 2; Myeloid translocation gene on chromosome 16 protein; hMTG16; Zinc finger MYND domain-containing protein 4 
Gene Name
 CBFA2T3 
Gene Synonyms/Alias
 MTG16; MTGR2; ZMYND4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70PDSPAEVKTQPRSTPubiquitination[1]
489VPEDIWRKAEEAVNEubiquitination[1]
498EEAVNEVKRQAMSELubiquitination[1]
535ERALAEAKRQASEDAubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. 
Sequence Annotation
 DOMAIN 171 266 TAFH.
 ZN_FING 556 592 MYND-type.
 REGION 1 435 Mediates localization to the nucleus (By
 REGION 1 430 Mediates interaction with PDE7A (in
 REGION 1 127 Required for nucleolar targeting (in
 REGION 485 506 Mediates interaction with PRKAR2A.
 CROSSLNK 535 535 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Chromosomal rearrangement; Coiled coil; Complete proteome; Differentiation; Golgi apparatus; Isopeptide bond; Membrane; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 653 AA 
Protein Sequence
MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP APVDRKAKAS 60
AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH THREDGPATL PHGRFHGCLK 120
WSMVCLLMNG SSHSPTAING APCTPNGFSN GPATSSTASL STQHLPPACG ARQLSKLKRF 180
LTTLQQFGSD ISPEIGERVR TLVLGLVNST LTIEEFHSKL QEATNFPLRP FVIPFLKANL 240
PLLQRELLHC ARLAKQTPAQ YLAQHEQLLL DASASSPIDS SELLLEVNEN GKRRTPDRTK 300
ENGSDRDPLH PEHLSKRPCT LNPAQRYSPS NGPPQPTPPP HYRLEDIAMA HHFRDAYRHP 360
DPRELRERHR PLVVPGSRQE EVIDHKLTER EWAEEWKHLN NLLNCIMDMV EKTRRSLTVL 420
RRCQEADREE LNHWARRYSD AEDTKKGPAP AAARPRSSSA GPEGPQLDVP REFLPRTLTG 480
YVPEDIWRKA EEAVNEVKRQ AMSELQKAVS DAERKAHELI TTERAKMERA LAEAKRQASE 540
DALTVINQQE DSSESCWNCG RKASETCSGC NAARYCGSFC QHRDWEKHHH VCGQSLQGPT 600
AVVADPVPGP PEAAHSLGPS LPVGAASPSE AGSAGPSRPG SPSPPGPLDT VPR 653 
Gene Ontology
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0030851; P:granulocyte differentiation; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR013289; ETO.
 IPR013292; MTG16.
 IPR014896; NHR2.
 IPR003894; TAFH_NHR1.
 IPR002893; Znf_MYND. 
Pfam
 PF08788; NHR2
 PF07531; TAFH
 PF01753; zf-MYND 
SMART
 SM00549; TAFH 
PROSITE
 PS51119; TAFH
 PS01360; ZF_MYND_1
 PS50865; ZF_MYND_2 
PRINTS
 PR01875; ETOFAMILY.
 PR01878; MTG16PROTEIN.