CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 70 
Protein Synonyms/Alias
 Synleurin 
Gene Name
 LRRC70 
Gene Synonyms/Alias
 UNQ1891/PRO4337 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
228SNAFEVLKSLRRLSLubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS). 
Sequence Annotation
 DOMAIN 32 60 LRRNT.
 REPEAT 61 82 LRR 1.
 REPEAT 85 106 LRR 2.
 REPEAT 109 130 LRR 3.
 REPEAT 133 154 LRR 4.
 REPEAT 157 178 LRR 5.
 REPEAT 181 202 LRR 6.
 REPEAT 205 226 LRR 7.
 REPEAT 229 250 LRR 8.
 REPEAT 253 274 LRR 9.
 REPEAT 277 298 LRR 10.
 REPEAT 301 322 LRR 11.
 REPEAT 326 347 LRR 12.
 DOMAIN 359 406 LRRCT.
 CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).
 CARBOHYD 266 266 N-linked (GlcNAc...) (Potential).
 CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
 CARBOHYD 400 400 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 622 AA 
Protein Sequence
MCGLQFSLPC LRLFLVVTCY LLLLLHKEIL GCSSVCQLCT GRQINCRNLG LSSIPKNFPE 60
STVFLYLTGN NISYINESEL TGLHSLVALY LDNSNILYVY PKAFVQLRHL YFLFLNNNFI 120
KRLDPGIFKG LLNLRNLYLQ YNQVSFVPRG VFNDLVSVQY LNLQRNRLTV LGSGTFVGMV 180
ALRILDLSNN NILRISESGF QHLENLACLY LGSNNLTKVP SNAFEVLKSL RRLSLSHNPI 240
EAIQPFAFKG LANLEYLLLK NSRIRNVTRD GFSGINNLKH LILSHNDLEN LNSDTFSLLK 300
NLIYLKLDRN RIISIDNDTF ENMGASLKIL NLSFNNLTAL HPRVLKPLSS LIHLQANSNP 360
WECNCKLLGL RDWLASSAIT LNIYCQNPPS MRGRALRYIN ITNCVTSSIN VSRAWAVVKS 420
PHIHHKTTAL MMAWHKVTTN GSPLENTETE NITFWERIPT SPAGRFFQEN AFGNPLETTA 480
VLPVQIQLTT SVTLNLEKNS ALPNDAASMS GKTSLICTQE VEKLNEAFDI LLAFFILACV 540
LIIFLIYKVV QFKQKLKASE NSRENRLEYY SFYQSARYNV TASICNTSPN SLESPGLEQI 600
RLHKQIVPEN EAQVILFEHS AL 622 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 
Pfam
 PF00560; LRR_1 
SMART
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 
PROSITE
 PS51450; LRR 
PRINTS