CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031285
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TOM1-like protein 1 
Protein Synonyms/Alias
 cDNA FLJ52768, highly similar to TOM1-like 1 protein 
Gene Name
 TOM1L1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26FVKENLVKLLNPRYNubiquitination[1]
71EVYLDLVKKGVQFPPubiquitination[1, 2, 3]
186QRILEQNKNQKEATNmethylation[4]
186QRILEQNKNQKEATNubiquitination[2, 3, 5]
189LEQNKNQKEATNTTSubiquitination[2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MCVQNCGPSF QSLIVKKEFV KENLVKLLNP RYNLPLDIQN RILNFIKTWS QGFPGGVDVS 60
EVKEVYLDLV KKGVQFPPSE AEAETARQEI GKLHSELDMV KMNVRVMSAI LMENTPGSEN 120
HEDIELLQKL YKTGREMQER IMDLLVVVEN EDVTVELIQV NEDLNNAILG YERFTRNQQR 180
ILEQNKNQKE ATNTTSEPSA PSQDLLDLSP SPRMPRATLG ELNTMNNQLS GLNFSLPSSD 240
VTNNLKPSLH PQMNLLALEN TEIPPFAQRT SQNLTSSHAY DNFLEHSNSV FLQPVSLQTI 300
AAAPSNQSLP PLPSNHPAMT KSDLQPPNYY EVMEFDPLAP AVTTEAIYEE IDAHQHKGAQ 360
NDGD 364 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0030295; F:protein kinase activator activity; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0045860; P:positive regulation of protein kinase activity; IEA:GOC. 
Interpro
 IPR008942; ENTH_VHS.
 IPR004152; GAT.
 IPR027428; TOM1L1.
 IPR002014; VHS. 
Pfam
 PF03127; GAT
 PF00790; VHS 
SMART
  
PROSITE
 PS50909; GAT
 PS50179; VHS 
PRINTS