UniProt Accession

 RAB43_MOUSE; Q8CG50 

Genbank Protein ID

 AJ534465 

Genbank Nucleotide ID

 CAD58914.1 

Protein Name

 Ras-related protein Rab-43 

Protein Synonyms/Alias

  

Gene Name

 Rab43 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
130	VQLLIGNKSDLADFR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. 

Sequence Annotation

 NP_BIND 23 30 GTP (By similarity).
 NP_BIND 71 75 GTP (By similarity).
 NP_BIND 129 132 GTP (By similarity).
 NP_BIND 161 162 GTP (By similarity).
 MOTIF 45 53 Effector region (By similarity).
 MOD_RES 80 80 Phosphothreonine.
 MOD_RES 210 210 Cysteine methyl ester (By similarity).
 LIPID 208 208 S-geranylgeranyl cysteine (By
 LIPID 210 210 S-geranylgeranyl cysteine (By  

Keyword

 Complete proteome; Cytoplasmic vesicle; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0007030; P:Golgi organization; ISS:UniProtKB.
 GO:0090382; P:phagosome maturation; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:InterPro.
 GO:0035526; P:retrograde transport, plasma membrane to Golgi; ISS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.