UniProt Accession

 TIE1_MOUSE; Q06806; Q811F4; Q8BGI2 

Genbank Protein ID

 X71425; X80764; X73960; AK052192; AK052413; AL627212; BC046452; S79346 

Genbank Nucleotide ID

 CAA50556.1; CAA56739.1; CAA52148.1; BAC34876.1; BAC34979.1; CAM15213.1; AAH46452.2 

Protein Name

 Tyrosine-protein kinase receptor Tie-1 

Protein Synonyms/Alias

  

Gene Name

 Tie1 

Gene Synonyms/Alias

 Tie; Tie-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
969	GMQYLSEKQFIHRDL	ubiquitination	[1]
990	VGENLASKIADFGLS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis (By similarity). 

Sequence Annotation

 DOMAIN 43 123 Ig-like C2-type 1.
 DOMAIN 212 254 EGF-like 1.
 DOMAIN 256 301 EGF-like 2.
 DOMAIN 303 343 EGF-like 3.
 DOMAIN 349 440 Ig-like C2-type 2.
 DOMAIN 444 539 Fibronectin type-III 1.
 DOMAIN 543 633 Fibronectin type-III 2.
 DOMAIN 640 732 Fibronectin type-III 3.
 DOMAIN 835 1114 Protein kinase.
 NP_BIND 841 849 ATP (By similarity).
 ACT_SITE 975 975 Proton acceptor (By similarity).
 BINDING 866 866 ATP (By similarity).
 MOD_RES 1003 1003 Phosphotyrosine; by autocatalysis (By
 CARBOHYD 81 81 N-linked (GlcNAc...) (Potential).
 CARBOHYD 159 159 N-linked (GlcNAc...) (Potential).
 CARBOHYD 501 501 N-linked (GlcNAc...) (Potential).
 CARBOHYD 592 592 N-linked (GlcNAc...) (Potential).
 CARBOHYD 705 705 N-linked (GlcNAc...) (Potential).
 DISULFID 226 235 By similarity.
 DISULFID 229 242 By similarity.
 DISULFID 244 253 By similarity.
 DISULFID 266 276 By similarity.
 DISULFID 270 289 By similarity.
 DISULFID 291 300 By similarity.
 DISULFID 313 325 By similarity.
 DISULFID 319 331 By similarity.
 DISULFID 333 342 By similarity.  

Keyword

 Angiogenesis; ATP-binding; Cell membrane; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1134 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISM:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0016525; P:negative regulation of angiogenesis; IMP:MGI.
 GO:0030336; P:negative regulation of cell migration; IMP:MGI.
 GO:0045026; P:plasma membrane fusion; IMP:MGI.
 GO:0032526; P:response to retinoic acid; IDA:BHF-UCL. 

Interpro

 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013151; Immunoglobulin.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 

Pfam

 PF00041; fn3
 PF12661; hEGF
 PF00047; ig
 PF07714; Pkinase_Tyr 

SMART

 SM00181; EGF
 SM00060; FN3
 SM00409; IG
 SM00219; TyrKc 

PROSITE

 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS50853; FN3
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 

PRINTS

 PR00109; TYRKINASE.