CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036316
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Endoplasmic reticulum aminopeptidase 2 
Protein Synonyms/Alias
  
Gene Name
 ERAP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138MKPGKELKVLSYPAHubiquitination[1]
155IALLVPEKLTPHLKYubiquitination[1]
181DGFEGFYKSTYRTLGubiquitination[1]
484GIIQYLKKFSYRNAKubiquitination[1]
491KFSYRNAKNDDLWSSubiquitination[1]
545MTTWTLQKGIPLLVVubiquitination[1]
553GIPLLVVKQDGCSLRubiquitination[1]
608HRHILKSKTDTLDLPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 694 AA 
Protein Sequence
MFHSSAMVNS HRKPMFNIHR GFYCLTAILP QICICSQFSV PSSYHFTEDP GAFPVATNGE 60
RFPWQELRLP SVVIPLHYDL FVHPNLTSLD FVASEKIEVL VSNATQFIIL HSKDLEITNA 120
TLQSEEDSRY MKPGKELKVL SYPAHEQIAL LVPEKLTPHL KYYVAMDFQA KLGDGFEGFY 180
KSTYRTLGGE TRILAVTDFE PTQARMAFPC FDEPLFKANF SIKIRRESRH IALSNMPKVK 240
TIELEGGLLE DHFETTVKMS TYLVAYIVCD FHSLSGFTSS GVKVSIYASP DKRNQTHYAL 300
QASLKLLDFY EKYFDIYYPL SKLDLIAIPD FAPGAMENWG LITYRETSLL FDPKTSSASD 360
KLWVTRVIAH ELAHQWFGNL VTMEWWNDIW LKEGFAKYME LIAVNATYPE LQFDDYFLNV 420
CFEVITKDSL NSSRPISKPA ETPTQIQEMF DEVSYNKGAC ILNMLKDFLG EEKFQKGIIQ 480
YLKKFSYRNA KNDDLWSSLS NSCLESDFTS GGVCHSDPKM TSNMLAFLGE NAEVKEMMTT 540
WTLQKGIPLL VVKQDGCSLR LQQERFLQGV FQEDPEWRAL QERYLWHIPL TYSTSSSNVI 600
HRHILKSKTD TLDLPEKTSW VKFNVDSNGY YIVHYEGHGW DQLITQLNQN HTLLRPKDRV 660
GLIHDVFQLV GAGRLTLDKA LDMTYYLQHE TSSP 694 
Gene Ontology
 GO:0008237; F:metallopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR024571; DUF3358.
 IPR001930; Peptidase_M1.
 IPR014782; Peptidase_M1_N. 
Pfam
 PF11838; DUF3358
 PF01433; Peptidase_M1 
SMART
  
PROSITE
  
PRINTS
 PR00756; ALADIPTASE.