CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004300
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin-2 
Protein Synonyms/Alias
 Neural cadherin; N-cadherin; CD325 
Gene Name
 Cdh2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
756RDKERQAKQLLIDPEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. 
Sequence Annotation
 DOMAIN 160 267 Cadherin 1.
 DOMAIN 268 382 Cadherin 2.
 DOMAIN 383 497 Cadherin 3.
 DOMAIN 498 603 Cadherin 4.
 DOMAIN 604 717 Cadherin 5.
 METAL 262 262 Calcium 1.
 METAL 262 262 Calcium 2.
 METAL 293 293 Calcium 3.
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
 CARBOHYD 273 273 N-linked (GlcNAc...) (Potential).
 CARBOHYD 325 325 N-linked (GlcNAc...) (Potential).
 CARBOHYD 402 402 N-linked (GlcNAc...) (Potential).
 CARBOHYD 572 572 N-linked (GlcNAc...) (Potential).
 CARBOHYD 651 651 N-linked (GlcNAc...) (Potential).
 CARBOHYD 692 692 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 906 AA 
Protein Sequence
MCRIAGAPRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLPKDVH EGQPLLNVKF 60
SNCNRKRKVQ YESSEPADFK VDEDGTVYAV RSFPLTAEQA KFLIYAQDKE TQEKWQVAVN 120
LSREPTLTEE PMKEPHEIEE IVFPRQLAKH SGALQRQKRD WVIPPINLPE NSRGPFPQEL 180
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV 240
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGSVPEGS KPGTYVMTVT AIDADDPNAL 300
NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV ANLTVTDKDQ PHTPAWNAAY 420
RISGGDPTGR FAILTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTLT AQDPDRYMQQ NIRYTKLSDP 540
ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
NAPQVLPQEA ETCETPEPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTINRLNGD 660
FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720
GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780
EDQDYDLSQL QQPDTVEPDA IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG DQDYDYLNDW GPRFKKLADM 900
YGGGDD 906 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0016342; C:catenin complex; IEA:Compara.
 GO:0005916; C:fascia adherens; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
 GO:0016339; P:calcium-dependent cell-cell adhesion; IDA:MGI.
 GO:0016477; P:cell migration; IDA:MGI.
 GO:0007157; P:heterophilic cell-cell adhesion; IDA:MGI.
 GO:0007156; P:homophilic cell adhesion; IDA:MGI.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IGI:MGI.
 GO:0043410; P:positive regulation of MAPK cascade; IGI:MGI.
 GO:0051146; P:striated muscle cell differentiation; IGI:MGI. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR009124; Cadherin/Desmocollin.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR014868; Cadherin_pro_dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C
 PF08758; Cadherin_pro 
SMART
 SM00112; CA
 SM01055; Cadherin_pro 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.
 PR01820; DESMOCOLLIN.