CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044634
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Voltage-dependent anion-selective channel protein 3 
Protein Synonyms/Alias
  
Gene Name
 Vdac3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12PTYCDLGKAAKDVFNacetylation[1, 2, 3]
15CDLGKAAKDVFNKGYacetylation[3, 4, 5]
15CDLGKAAKDVFNKGYphosphoglycerylation[6]
15CDLGKAAKDVFNKGYubiquitination[7]
20AAKDVFNKGYGFGMVacetylation[1, 3, 4, 5, 8, 9]
20AAKDVFNKGYGFGMVphosphoglycerylation[6]
20AAKDVFNKGYGFGMVubiquitination[7]
28GYGFGMVKIDLKTKSacetylation[3, 4, 8, 9]
28GYGFGMVKIDLKTKSubiquitination[7]
62ASGNLETKYKVCNYGacetylation[1, 3, 4, 5]
64GNLETKYKVCNYGLTacetylation[1, 3, 4, 5, 8, 9]
64GNLETKYKVCNYGLTubiquitination[7]
91TEISWENKLAEGLKLacetylation[1, 4, 9]
91TEISWENKLAEGLKLubiquitination[7]
110IFVPNTGKKSGKLKAacetylation[4]
110IFVPNTGKKSGKLKAubiquitination[7]
164SFDTAKSKLSQNNFAacetylation[1, 4, 5, 8]
164SFDTAKSKLSQNNFAubiquitination[7]
175NNFALGYKAADFQLHacetylation[2, 9]
225TRFGIAAKYKLDCRTacetylation[1, 3, 4, 5]
225TRFGIAAKYKLDCRTsuccinylation[3]
227FGIAAKYKLDCRTSLacetylation[1, 4, 5]
267LSALIDGKNFNAGGHacetylation[3, 4]
267LSALIDGKNFNAGGHubiquitination[7]
275NFNAGGHKVGLGFELubiquitination[7]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
 [7] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [8] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [9] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVV EFSTSGHAYT DTGKASGNLE 60
TKYKVCNYGL TFTQKWNTDN TLGTEISWEN KLAEGLKLTL DTIFVPNTGK KSGKLKASYR 120
RDCFSLGSNV DIDFSGPTIY GWAVLAFEGW LAGYQMSFDT AKSKLSQNNF ALGYKAADFQ 180
LHTHVNDGTE FGGSIYQKVN ERIETSINLA WTAGSNNTRF GIAAKYKLDC RTSLSAKVNN 240
ASLIGLGYTQ TLRPGVKLTL SALIDGKNFN AGGHKVGLGF ELEA 284 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005741; C:mitochondrial outer membrane; IEA:InterPro.
 GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro.
 GO:0001662; P:behavioral fear response; IMP:MGI.
 GO:0007612; P:learning; IMP:MGI.
 GO:0007270; P:neuron-neuron synaptic transmission; IMP:MGI. 
Interpro
 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 
Pfam
 PF01459; Porin_3 
SMART
  
PROSITE
 PS00558; EUKARYOTIC_PORIN 
PRINTS
 PR00185; EUKARYTPORIN.