UniProt Accession

 SOMA_BOVIN; P01246; A4GX96; Q28117; Q3LS73 

Genbank Protein ID

 V00111; J00008; M27325; M57764; M23813; AF034386; DQ184480; EF451795; EF451796; M11558 

Genbank Nucleotide ID

 CAA23445.1; AAA30542.1; AAA30543.1; AAA30544.1; AAA30556.1; AAB92549.1; ABA26924.1; ABO21739.1; ABO21740.1; AAA30545.1 

Protein Name

 Somatotropin 

Protein Synonyms/Alias

 Growth hormone 

Gene Name

 GH1 

Gene Synonyms/Alias

 GH 

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
170	ILKQTYDKFDTNMRS	acetylation	[1]
183	RSDDALLKNYGLLSC	acetylation	[1]
193	GLLSCFRKDLHKTET	acetylation	[1]
197	CFRKDLHKTETYLRV	acetylation	[1]
206	ETYLRVMKCRRFGEA	acetylation	[1]

Reference

 [1] Isolation of Escherichia coli synthesized recombinant eukaryotic proteins that contain epsilon-N-acetyllysine.
 Violand BN, Schlittler MR, Lawson CQ, Kane JF, Siegel NR, Smith CE, Kolodziej EW, Duffin KL.
 Protein Sci. 1994 Jul;3(7):1089-97. [PMID: 7920255] 

Functional Description

 Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. 

Sequence Annotation

 METAL 46 46 Zinc (By similarity).
 METAL 199 199 Zinc (By similarity).
 MOD_RES 132 132 Phosphoserine (By similarity).
 DISULFID 79 190
 DISULFID 207 215  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0005131; F:growth hormone receptor binding; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0033143; P:regulation of intracellular steroid hormone receptor signaling pathway; IDA:MGI.
 GO:0032094; P:response to food; IEA:Compara. 

Interpro

 IPR009079; 4_helix_cytokine-like_core.
 IPR012351; 4_helix_cytokine_core.
 IPR001400; Somatotropin.
 IPR018116; Somatotropin_CS. 

Pfam

 PF00103; Hormone_1 

SMART

  

PROSITE

 PS00266; SOMATOTROPIN_1
 PS00338; SOMATOTROPIN_2 

PRINTS

 PR00836; SOMATOTROPIN.