CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043423
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dual-specificity protein kinase CLK3 
Protein Synonyms/Alias
  
Gene Name
 CLK3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
203LGEGTFGKVVECLDHubiquitination[1, 2]
214CLDHARGKSQVALKIubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
SGRGARSGEW GLAAAGAWET MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR 60
EPPPRRSRSR SKDPADQRPH PPFGSHDRLP YQRRYRERRD SDTYRCEERS PSFGEDYYGP 120
SRSRHRRRSR ERGPYRTRKH AHHCHKRRTR SCSSASSRSQ QSSKRSSRSV EDDKEGHLVC 180
RIGDWLQERY EIVGNLGEGT FGKVVECLDH ARGKSQVALK IIRNVGKYRE AARLEINVLK 240
KIKEKDKENK FLCVLMSDWF NFHGHMCIAF ELLGKNTFEF LKENNFQPYP LPHVRHMAYQ 300
LCHALR 306 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM 
PRINTS