CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020431
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat and coiled-coil domain-containing protein 1 
Protein Synonyms/Alias
 Centrosomal leucine-rich repeat and coiled-coil domain-containing protein 
Gene Name
 LRRCC1 
Gene Synonyms/Alias
 CLERC; KIAA1764 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
134LIPLHGIKHKLRYIDubiquitination[1]
405PMLQESEKPKTEIIKubiquitination[1]
476LLTTDRLKEIIFRERubiquitination[1]
501HKLQNEIKKLTVELMubiquitination[1]
609DFQDALAKEIAKEEKubiquitination[1]
658ARRFQDVKDGFENVAubiquitination[1]
672ATELAKSKHALIWAQubiquitination[1]
690NESSSLIKDLTCMVKubiquitination[1]
708TKLAEVSKLKQETAAubiquitination[1]
710LAEVSKLKQETAANLubiquitination[1]
767FGLRTERKVWGHELAubiquitination[2, 3]
846HIKRLQEKITEIEKCubiquitination[1]
852EKITEIEKCTQEQLDubiquitination[1]
952LQKNAMEKLHSMDDAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. 
Sequence Annotation
 REPEAT 44 65 LRR 1.
 REPEAT 66 87 LRR 2.
 REPEAT 88 109 LRR 3.
 REPEAT 110 131 LRR 4.
 REPEAT 136 157 LRR 5.
 DOMAIN 175 218 LRRCT.  
Keyword
 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Mitosis; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1032 AA 
Protein Sequence
MEAAAAVVAA EAEVENEDGD SSCGDVCFMD KGLQSISELS LDSTLHAVNL HCNNISKIEA 60
IDHIWNLQHL DLSSNQISRI EGLNTLTKLC TLNLSCNLIT KVEGLEELIN LTRLNVSYNH 120
IDDLSGLIPL HGIKHKLRYI DLHSNRIDSI HHLLQCMVGL HFLTNLILEK DGDDNPVCRL 180
PGYRAVILQT LPQLRILDCK NIFGEPVNLT EINSSQLQCL EGLLDNLVSS DSPLNISEDE 240
IIDRMPVITA PIDELVPLEQ FASTPSDAVL TSFMSVCQSS EPEKNNHEND LQNEIKLQKL 300
DDQILQLLNE TSNSIDNVLE KDPRPKRDTD ITSESDYGNR KECNRKVPRR SKIPYDAKTI 360
QTIKHHNKNY NSFVSCNRKM KPPYLKELYV SSSLANCPML QESEKPKTEI IKVDQSHSED 420
NTYQSLVEQL DQEREKRWRA EQAENKLMDY IDELHKHANE KEDIHSLALL TTDRLKEIIF 480
RERNSKGQLE VMVHKLQNEI KKLTVELMKA KDQQEDHLKH LRTLEKTLEK MERQKRQQQA 540
AQIRLIQEVE LKASAADREI YLLRTSLHRE REQAQQLHQL LALKEQEHRK ELETREFFTD 600
ADFQDALAKE IAKEEKKHEQ MIKEYQEKID VLSQQYMDLE NEFRIALTVE ARRFQDVKDG 660
FENVATELAK SKHALIWAQR KENESSSLIK DLTCMVKEQK TKLAEVSKLK QETAANLQNQ 720
INTLEILIED DKQKSIQIEL LKHEKVQLIS ELAAKESLIF GLRTERKVWG HELAQQGSSL 780
AQNRGKLEAQ IESLSRENEC LRKTNESDSD ALRIKCKIID DQTETIRKLK DCLQEKDEHI 840
KRLQEKITEI EKCTQEQLDE KSSQLDEVLE KLERHNERKE KLKQQLKGKE VELEEIRKAY 900
STLNRKWHDK GELLCHLETQ VKEVKEKFEN KEKKLKAERD KSIELQKNAM EKLHSMDDAF 960
KRQVDAIVEA HQAEIAQLAN EKQKCIDSAN LKVHQIEKEM RELLEETCKN KKTMEAKIKQ 1020
LAFALNEIQQ DM 1032 
Gene Ontology
 GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003603; U2A'_phosphoprotein32A_C. 
Pfam
 PF00560; LRR_1
 PF12799; LRR_4 
SMART
 SM00446; LRRcap 
PROSITE
 PS51450; LRR 
PRINTS