CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006156
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Poliovirus receptor-related protein 2 
Protein Synonyms/Alias
 Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Murine herpes virus entry protein B; mHveB; Nectin-2; Poliovirus receptor homolog; CD112 
Gene Name
 Pvrl2 
Gene Synonyms/Alias
 Mph; Pvr; Pvs 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
398DRGSYDPKTQVFGNGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable cell adhesion protein. 
Sequence Annotation
 DOMAIN 32 147 Ig-like V-type.
 DOMAIN 153 247 Ig-like C2-type 1.
 DOMAIN 252 337 Ig-like C2-type 2.
 MOD_RES 424 424 Phosphoserine (By similarity).
 CARBOHYD 128 128 N-linked (GlcNAc...).
 CARBOHYD 138 138 N-linked (GlcNAc...).
 CARBOHYD 315 315 N-linked (GlcNAc...).
 DISULFID 54 131
 DISULFID 174 229
 DISULFID 274 320 By similarity.  
Keyword
 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 530 AA 
Protein Sequence
MARAAVLPPS RLSPTLPLLP LLLLLLQETG AQDVRVRVLP EVRGRLGGTV ELPCHLLPPT 60
TERVSQVTWQ RLDGTVVAAF HPSFGVDFPN SQFSKDRLSF VRARPETNAD LRDATLAFRG 120
LRVEDEGNYT CEFATFPNGT RRGVTWLRVI AQPENHAEAQ EVTIGPQSVA VARCVSTGGR 180
PPARITWISS LGGEAKDTQE PGIQAGTVTI ISRYSLVPVG RADGVKVTCR VEHESFEEPI 240
LLPVTLSVRY PPEVSISGYD DNWYLGRSEA ILTCDVRSNP EPTDYDWSTT SGVFPASAVA 300
QGSQLLVHSV DRMVNTTFIC TATNAVGTGR AEQVILVRDT PQASRDVGPL VWGAVGGTLL 360
VLLLAGGFLA LILLRGRRRR KSPGGGGNDG DRGSYDPKTQ VFGNGGPVFW RSASPEPMRP 420
DGREEDEEEE EEMKAEEGLM LPPHESPKDD MESHLDGSLI SRRAVYV 467 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:HGNC.
 GO:0005915; C:zonula adherens; IDA:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:HGNC.
 GO:0001675; P:acrosome assembly; IMP:MGI.
 GO:0051856; P:adhesion to symbiont; IEA:Compara.
 GO:0032990; P:cell part morphogenesis; IMP:MGI.
 GO:0007010; P:cytoskeleton organization; IMP:MGI.
 GO:0051654; P:establishment of mitochondrion localization; IMP:MGI.
 GO:0009566; P:fertilization; IMP:MGI.
 GO:0043064; P:flagellum organization; IMP:MGI.
 GO:0007156; P:homophilic cell adhesion; IDA:HGNC.
 GO:0002891; P:positive regulation of immunoglobulin mediated immune response; IEA:Compara.
 GO:0033005; P:positive regulation of mast cell activation; IEA:Compara.
 GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IEA:Compara.
 GO:0030382; P:sperm mitochondrion organization; IMP:MGI.
 GO:0007289; P:spermatid nucleus differentiation; IMP:MGI.
 GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IEA:Compara.
 GO:0060370; P:susceptibility to T cell mediated cytotoxicity; IEA:Compara.
 GO:0019064; P:viral entry into host cell via membrane fusion with the plasma membrane; IEA:Compara.
 GO:0046814; P:virion attachment, binding of host cell surface coreceptor; IEA:Compara. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013106; Ig_V-set.
 IPR003596; Ig_V-set_subgr. 
Pfam
 PF08205; C2-set_2
 PF07686; V-set 
SMART
 SM00406; IGv 
PROSITE
 PS50835; IG_LIKE 
PRINTS