CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041609
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldehyde dehydrogenase family 6, subfamily A1, isoform CRA_b 
Protein Synonyms/Alias
 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial 
Gene Name
 Aldh6a1 
Gene Synonyms/Alias
 rCG_20746 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
47VKLFIDGKFVESKSDacetylation[1]
52DGKFVESKSDKWIDIacetylation[1]
55FVESKSDKWIDIHNPacetylation[1]
76GRVPQSTKAEMEAAVacetylation[1]
113LRYQQLIKENLKEIAacetylation[1]
117QLIKENLKEIARLITacetylation[1]
129LITLEQGKTLADAEGacetylation[1]
298VVMPDANKENTLNQLacetylation[1]
331VLVGEAKKWLPELVEacetylation[1]
364PLITPQAKERVCNLIacetylation[1]
376NLIDSGAKEGASILLacetylation[1]
517KTITSQWKEEDATLSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 535 AA 
Protein Sequence
MAAAVAAAAA VRSRILQVSS KVNSTWCPAS SFSSSSVPTV KLFIDGKFVE SKSDKWIDIH 60
NPATNEVVGR VPQSTKAEME AAVAACKRAF PAWADTSILS RQQVLLRYQQ LIKENLKEIA 120
RLITLEQGKT LADAEGDVFR GLQVVEHACS VTSLMLGETM PSITKDMDLY SYRLPLGVCA 180
GIAPFNFPAM IPLWMFPMAM VCGNTFLMKP SERVPGATML LAKLLQDSGA PDGTLNIIHG 240
QHEAVNFICD HPDIKAISFV GSNQAGEYIF ERGSRNGKRV QANMGAKNHG VVMPDANKEN 300
TLNQLVGAAF GAAGQRCMAL STAVLVGEAK KWLPELVERA KNLRVNAGDQ PGADLGPLIT 360
PQAKERVCNL IDSGAKEGAS ILLDGRKIKV KGYENGNFVG PTIISNVKPS MTCYKEEIFG 420
PVLVVLETET LDEAIKIVND NPYGNGTAIF TTNGAIARKY AHMVDVGQVG VNVPIPVPLP 480
MFSFTGSRSS FRGDTNFYGK QGIQFYTQLK TITSQWKEED ATLSSPAVVM PTMGR 535 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating) activity; IEA:InterPro.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010061; MeMal-semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS 
PRINTS