UniProt Accession

 VPS4_YEAST; P52917; D6W4H4 

Genbank Protein ID

 X92680; U25842; BK006949 

Genbank Nucleotide ID

 CAA63364.1; AAB68107.1; DAA11590.1 

Protein Name

 Vacuolar protein sorting-associated protein 4 

Protein Synonyms/Alias

 DOA4-independent degradation protein 6; Protein END13; Vacuolar protein-targeting protein 10 

Gene Name

 VPS4 

Gene Synonyms/Alias

 CSC1; DID6; END13; GRD13; VPL4; VPT10; YPR173C; P9705.10 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
59	SKDLIRAKFTEYLNR	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. 

Sequence Annotation

 DOMAIN 3 80 MIT.
 NP_BIND 173 180 ATP (Potential).  

Keyword

 3D-structure; ATP-binding; Complete proteome; Endosome; Membrane; Nucleotide-binding; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 437 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0005768; C:endosome; IDA:SGD.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IDA:SGD.
 GO:0005524; F:ATP binding; IDA:SGD.
 GO:0016887; F:ATPase activity; IDA:SGD.
 GO:0042803; F:protein homodimerization activity; IDA:SGD.
 GO:0070676; P:intralumenal vesicle formation; IMP:SGD.
 GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IMP:SGD.
 GO:0051260; P:protein homooligomerization; IDA:SGD.
 GO:0045053; P:protein retention in Golgi apparatus; IMP:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0016125; P:sterol metabolic process; IMP:SGD. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR007330; MIT.
 IPR027417; P-loop_NTPase.
 IPR015415; Vps4_C. 

Pfam

 PF00004; AAA
 PF04212; MIT
 PF09336; Vps4_C 

SMART

 SM00382; AAA
 SM00745; MIT 

PROSITE

 PS00674; AAA 

PRINTS