CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026400
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tripeptidyl-peptidase 2 
Protein Synonyms/Alias
  
Gene Name
 TPP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19FHGLLPKKETGAASFubiquitination[1, 2]
109SWTNPSGKYHIGIKNubiquitination[2]
152ALAEACRKQEEFDVAubiquitination[2]
220NEDGDLSKSTVLRNYubiquitination[2]
321MIEVINHKCDLVNYSubiquitination[2]
401AEYSLREKLPANQYTubiquitination[2]
655AFTDVHFKPGQIRRHubiquitination[2]
697LHAVQLVKQRAYRSHubiquitination[2]
708YRSHEFYKFCSLPEKubiquitination[2]
715KFCSLPEKGTLTEAFubiquitination[2]
904ISDLERLKDLPFIVSubiquitination[2]
958VTSLPDDKIPKGAGPubiquitination[2]
1042TEALRDLKIQWMTKLubiquitination[2]
1080LHQLDAEKERMKRLNubiquitination[2]
1193WTDLFDNKVLTFAYKubiquitination[2]
1200KVLTFAYKHALVNKMubiquitination[2]
1206YKHALVNKMYGRGLKubiquitination[2]
1213KMYGRGLKFATKLVEubiquitination[2]
1217RGLKFATKLVEEKPTubiquitination[2]
1225LVEEKPTKENWKNCIubiquitination[2]
1229KPTKENWKNCIQLMKubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1262 AA 
Protein Sequence
MATAATEEPF PFHGLLPKKE TGAASFLCRY PEYDGRGVLI AVLDTGVDPG APGMQVTTDG 60
KPKIVDIIDT TGSGDVNTAT EVEPKDGEIV GLSGRVLKIP ASWTNPSGKY HIGIKNGYDF 120
YPKALKERIQ KERKEKIWDP VHRVALAEAC RKQEEFDVAN NGSSQANKLI KEELQSQVEL 180
LNSFEKKYSD PGPVYDCLVW HDGEVWRACI DSNEDGDLSK STVLRNYKEA QEYGSFGTAE 240
MLNYSVNIYD DGNLLSIVTS GGAHGTHVAS IAAGHFPEEP ERNGVAPGAQ ILSIKIGDTR 300
LSTMETGTGL IRAMIEVINH KCDLVNYSYG EATHWPNSGR ICEVINEAVW KHNIIYVSSA 360
GNNGPCLSTV GCPGGTTSSV IGVGAYVSPD MMVAEYSLRE KLPANQYTWS SRGPSADGAL 420
GVSISAPGGA IASVPNWTLR GTQLMNGTSM SSPNACGGIA LILSGLKANN IDYTVHSVRR 480
ALENTAVKAD NIEVFAQGHG IIQVDKAYDY LVQNTSFANK LGFTVTVGNN RGIYLRDPVQ 540
VAAPSDHGVG IEPVFPENTE NSEKISLQLH LALTSNSSWV QCPSHLELMN QCRHINIRVD 600
PRGLREGLHY TEVCGYDIAS PNAGPLFRVP ITAVIAAKVN ESSHYDLAFT DVHFKPGQIR 660
RHFIEVPEGA TWAEVTVCSC SSEVSAKFVL HAVQLVKQRA YRSHEFYKFC SLPEKGTLTE 720
AFPVLGGKAI EFCIARWWAS LSDVNIDYTI SFHGIVCTAP QLNIHASEGI NRFDVQSSLK 780
YEDLAPCITL KNWVQTLRPV SAKTKPLGSR DVLPNNRQLY EMVLTYNFHQ PKSGEVTPSC 840
PLLCELLYES EFDSQLWIIF DQNKRQMGSG DAYPHQYSLK LEKGDYTIRL QIRHEQISDL 900
ERLKDLPFIV SHRLSNTLSL DIHENHSFAL LGKKKSSNLT LPPKYNQPFF VTSLPDDKIP 960
KGAGPGCYLA GSLTLSKTEL GKKAGQSAAK RQGKFKKDVI PVHYYLIPPP TKTKNGSKDK 1020
EKDSEKEKDL KEEFTEALRD LKIQWMTKLD SSDIYNELKE TYPNYLPLYV ARLHQLDAEK 1080
ERMKRLNEIV DAANAVISHI DQTALAVYIA MKTDPRPDAA TIKNDMDKQK STLVDALCRK 1140
GCALADHLLH TQAQDGAIST DAEGKEEEGE SPLDSLAETF WETTKWTDLF DNKVLTFAYK 1200
HALVNKMYGR GLKFATKLVE EKPTKENWKN CIQLMKLLGW THCASFTENW LPIMYPPDYC 1260
VF 1262 
Gene Ontology
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR000209; Peptidase_S8/S53_dom.
 IPR022398; Peptidase_S8_His-AS.
 IPR023828; Peptidase_S8_Ser-AS.
 IPR015500; Peptidase_S8_subtilisin-rel.
 IPR022229; Peptidase_S8A_TPPII. 
Pfam
 PF00082; Peptidase_S8
 PF12580; TPPII 
SMART
  
PROSITE
 PS00137; SUBTILASE_HIS
 PS00138; SUBTILASE_SER 
PRINTS
 PR00723; SUBTILISIN.