| Tag | Content |
|---|
| CPLM ID | CPLM-014898 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 |
Protein Synonyms/Alias | E-NPP 3; Phosphodiesterase I beta; PD-Ibeta; Phosphodiesterase I/nucleotide pyrophosphatase 3; CD203c; Alkaline phosphodiesterase I; Nucleotide pyrophosphatase; NPPase |
Gene Name | Enpp3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 14 | LATEEPIKKDSLKKY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD (By similarity). |
Sequence Annotation | DOMAIN 51 93 SMB 1.
DOMAIN 94 138 SMB 2.
REGION 140 509 Phosphodiesterase.
REGION 605 874 Nuclease.
MOTIF 78 80 Cell attachment site (Potential).
ACT_SITE 205 205 AMP-threonine intermediate (By
METAL 167 167 Divalent metal cation 2 (Probable).
METAL 325 325 Divalent metal cation 1 (Probable).
METAL 329 329 Divalent metal cation 1 (Probable).
METAL 372 372 Divalent metal cation 2 (Probable).
METAL 373 373 Divalent metal cation 2 (Probable).
METAL 482 482 Divalent metal cation 1 (Probable).
CARBOHYD 236 236 N-linked (GlcNAc...) (Potential).
CARBOHYD 279 279 N-linked (GlcNAc...) (Potential).
CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
CARBOHYD 425 425 N-linked (GlcNAc...) (Potential).
CARBOHYD 532 532 N-linked (GlcNAc...) (Potential).
CARBOHYD 594 594 N-linked (GlcNAc...).
CARBOHYD 687 687 N-linked (GlcNAc...) (Potential).
CARBOHYD 701 701 N-linked (GlcNAc...) (Potential).
CARBOHYD 820 820 N-linked (GlcNAc...) (Potential).
DISULFID 54 71 Alternate (By similarity).
DISULFID 54 58 Alternate (By similarity).
DISULFID 58 89 Alternate (By similarity).
DISULFID 69 82 Alternate (By similarity).
DISULFID 69 71 Alternate (By similarity).
DISULFID 75 81 By similarity.
DISULFID 82 89 Alternate (By similarity).
DISULFID 98 115 Alternate (By similarity).
DISULFID 98 103 Alternate (By similarity).
DISULFID 103 133 Alternate (By similarity).
DISULFID 113 126 Alternate (By similarity).
DISULFID 113 115 Alternate (By similarity).
DISULFID 119 125 By similarity.
DISULFID 126 133 Alternate (By similarity). |
Keyword | Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Membrane; Metal-binding; Multifunctional enzyme; Reference proteome; Repeat; Secreted; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 874 AA |
Protein Sequence | MDSRLALATE EPIKKDSLKK YKILCVVLLA LLVIVSLGLG LGLGLRKPEE QGSCRKKCFD 60
SSHRGLEGCR CDSGCTGRGD CCWDFEDTCV KSTQIWTCNL FRCGENRLET ALCSCADDCL 120
QRKDCCADYK TVCQGESPWV TEACASSQEP QCPPGFDLPP VILFSMDGFR AEYLQTWSTL 180
LPNINKLKTC GIHSKYMRAM YPTKTFPNHY TIVTGLYPES HGIIDNNMYD VHLNKNFSLS 240
SVEKSNPAWW SGQPIWLTAM YQGLKAACYY WPGSDVAVNG SFPTIYRNYS NSVPYERRIT 300
TLLQWLDLPK ADRPSFYTIY VEEPDSAGHS SGPVSAGVIK ALQSVDNAFG MLMEGLKQRN 360
LHNCVNIIVL ADHGMDQTSC DRVEYMTDYF PKINFYMYQG PAPRIRTRNI PQDFFTFNSE 420
EIVRNLSCRK PDQHFKPYLT PDLPKRLHYA KNVRIDKAHL MVDRQWLAFR SKGSSNCGGG 480
THGYNNEFKS MEAIFLAHGP SFIEKTVIEP FENIEVYNLL CDLLHIEPAP NNGTHGSLNH 540
LLKTPFYKPS HAGELSTPAD CGFTTPLPTD PLDCSCPALQ NTPGLEEQAN QRLNLSEGEV 600
AATVKANLPF GRPRVMQKNG DHCLLYHRDY ISGYGKAMKM PMWSSYTVLK PGDTSSLPPT 660
VPDCLRADVR VAPSESQKCS FYLADKNITH GFLYPAIKGT NESRYDALIT SNLVPMYKEF 720
KKMWDYFHEV LLIKYAIERN GLNVVSGPIF DYNYDGHFDA PDEITQYVAG TDVPIPTHYF 780
VVLTSCKDQT HTPDSCPGWL DVLPFIVPHR PTNIESCSEN KTEDLWVEER FQAHAARVRD 840
VELLTGLDFY QEKAQPVSQI LQLKTYLPTF ETII 874 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0035529; F:NADH pyrophosphatase activity; IEA:EC. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IEA:Compara. GO:0004528; F:phosphodiesterase I activity; IEA:EC. GO:0030247; F:polysaccharide binding; IEA:InterPro. GO:0005044; F:scavenger receptor activity; IEA:InterPro. GO:0006955; P:immune response; IEA:InterPro. GO:0009143; P:nucleoside triphosphate catabolic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |