| Tag | Content |
|---|
| CPLM ID | CPLM-014335 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | H(+)/Cl(-) exchange transporter 4 |
Protein Synonyms/Alias | Chloride channel protein 4; ClC-4; Chloride transporter ClC-4 |
Gene Name | Clcn4 |
Gene Synonyms/Alias | Clc4; Clcn4-2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 646 | RELILAIKNARQRQE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). |
Sequence Annotation | DOMAIN 587 653 CBS 1.
DOMAIN 680 742 CBS 2.
NP_BIND 618 620 ATP (By similarity).
NP_BIND 725 728 ATP (By similarity).
MOTIF 167 171 Selectivity filter part_1 (By
MOTIF 209 213 Selectivity filter part_2 (By
MOTIF 454 458 Selectivity filter part_3 (By
BINDING 168 168 Chloride (By similarity).
BINDING 456 456 Chloride; via amide nitrogen (By
BINDING 559 559 Chloride (By similarity).
BINDING 597 597 ATP; via amide nitrogen and carbonyl |
Keyword | Antiport; ATP-binding; CBS domain; Chloride; Complete proteome; Endosome; Ion transport; Membrane; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 747 AA |
Protein Sequence | MDFLEEPFPD VGTYEDFHTI DWLREKSRDT DRHRKITSKS KESIWEFIKS LLDAWSGWVV 60
MLLIGLLAGT LAGVIDLAVD WMTDLKEGVC LSAFWYSHEQ CCWTSNETTF EDRDKCPLWQ 120
KWSELLLSQS EGASAYILNY LMYILWALLF AFLAVSLVRV FAPYACGSGI PEIKTILSGF 180
IIRGYLGKWT LLIKTVTLVL VVSSGLSLGK EGPLVHVACC CGNFFSSLFS KYSKNEGKRR 240
EVLSAAAAAG VSVAFGAPIG GVLFSLEEVS YYFPLKTLWR SFFAALVAAF TLRSINPFGN 300
SRLVLFYVEY HTPWYMAELF PFILLGVFGG LWGTLFTRCN IAWCRRRKTT RLGRYPVLEV 360
IAVTAVTAIV AYPNPYTRQS TSELISELFN DCGALESSQL CDYINDPNMT RPVDDIPDRP 420
AGVGVYTAMW QLALALIFKI VITIFTFGMK IPSGLFIPSM AVGAMAGRMV GIGVEQLAYH 480
HHDWIIFRNW CRPGADCVTP GLYAMVGAAA CLGGVTRMTV SLVVIMFELT GGLEYIVPLM 540
AAAVTSKWVA DAFGKEGIYE AHIHLNGYPF LDVKDEFTHR TLATDVMRPR RGEPPLSVLT 600
QDSMTVEDVE TLIKETDYNG FPVLVSRDSE RLIGFAQRRE LILAIKNARQ RQEGIVSNSI 660
MYFTEEPPEL PANSPHPLKL RRILNLSPFT VTDHTPMETV VDIFRKLGLR QCLVTRSGRL 720
LGIITKKDVL RHMAQMANQD PESIMFN 747 |
Gene Ontology | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. GO:0015297; F:antiporter activity; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |