UniProt Accession

 E7EPD8_HUMAN; E7EPD8 

Genbank Protein ID

 AL137128 

Genbank Nucleotide ID

  

Protein Name

 Tyrosyl-DNA phosphodiesterase 1 

Protein Synonyms/Alias

  

Gene Name

 TDP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
114	KVVIKKEKDISAPND	ubiquitination	[1, 2]
139	APACHRLKEEEDEYE	ubiquitination	[3]
367	GRFQGSQKDNWGHFR	ubiquitination	[1]
417	KWLCSEFKESMLTLG	ubiquitination	[1]
432	KESKTPGKSSVPLYL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 589 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro. 

Interpro

 IPR027415; TDP_C.
 IPR010347; Tyr-DNA_phospho. 

Pfam

 PF06087; Tyr-DNA_phospho 

SMART

  

PROSITE

  

PRINTS